PREPARATION AND PURIFICATION OF ARACHIDONIC-ACID HYDROPEROXIDES OF BIOLOGICAL IMPORTANCE

被引：179
作者：
PORTER, NA
LOGAN, J
KONTOYIANNIDOU, V
机构：
[1] Paul M. Gross Chemical Laboratories, Duke University, Durham
来源：
JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 18期
关键词：
D O I：
10.1021/jo01332a017
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Singlet oxygen oxidation of arachidonic acid (5, 8, 11, 14-eicosatetraenoic acid) leads to eight hydroperoxides that may be separated by high-pressure liquid chromatography. The hydroperoxides result from allylic oxidation of one of the double bonds of the polyene fatty acid, a trans double bond being formed in the process. 12-(Hydroperoxy)eicosatetraenoic acid, 12-HPETE, a biologically important hydroperoxide formed from arachidonic acid and a lipoxygenase enzyme present in blood platelets, may be prepared by this approach. © 1979, American Chemical Society. All rights reserved.
引用
收藏
页码：3177 / 3181
页数：5
相关论文
共 24 条
123