ECHINOMYCIN (NSC-526417) IN SQUAMOUS-CELL CARCINOMA OF THE CERVIX - A PHASE-II TRIAL OF THE GYNECOLOGIC ONCOLOGY GROUP

被引：23
作者：
MUSS, HB
BLESSING, JA
MALFETANO, J
机构：
[1] ALBANY MED CTR,DEPT OBSTET & GYNECOL,ALBANY,NY
[2] WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT MED,WINSTON SALEM,NC 27103
[3] NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,GYNECOL ONCOL GRP,DEPT STAT,BUFFALO,NY 14263
来源：
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 1990年 / 13卷 / 03期
关键词：
D O I：
10.1097/00000421-199006000-00002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Twenty-eight evaluable patients with advanced or recurrent squamous-cell carcinoma of the cervix were treated with 1,500 μg/m2 of echinomycin every 4 weeks. All patients had prior chemotherapy. Two patients had partial responses (7% response, 95% confidence interval for response of 1 to 24%). The major toxicity was nausea and vomiting. Myelosuppression and other toxicity were modest. Echinomycin, at this dose and schedule, displays minimal activity in patients with squamous-cell carcinoma of the cervix who have had prior chemotherapy.
引用
收藏
页码：191 / 193
页数：3
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