EFFECT OF N,N'-BIS(METHYLISATIN-BETA-THIOSEMICARBAZONE)-2-METHYLPIPERAZINE ON VACCINIA VIRUS-REPLICATION INVITRO AND INVIVO

被引：9

作者：

BORYSIEWICZ, J ^{[1
]}

WITALINSKI, W ^{[1
]}

机构：

[1] JAGIELLONIAN UNIV,DEPT COMPARAT MED,PL-30060 CRACOW,POLAND

来源：

ARCHIVES OF VIROLOGY | 1979年 / 62卷 / 01期

关键词：

D O I：

10.1007/BF01314907

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The inhibitory effect of N,N′-bis(methylisatin-β-thiosemicarbazone)-2-methylpiperazine (compound TSKI-VI) and methisazone (Marboran) on the growth of vaccinia virus (IHD strain) was studied in vitro and in vivo. The therapeutic indices of both compounds determined in vivo were similar, but TSKI-VI was found more efficient in vitro. © 1979 Springer-Verlag.

引用

页码：83 / 86

页数：4

共 12 条

[1]

BAUER DJ, 1960, LANCET, V1, P1110

[2]

BAUER DJ, 1963, LANCET, V2, P494

[3]

BORYSIEWICZ J, 1976, ACTA VIROL, V20, P402

[4]

BORYSIEWICZ J, 1978, ACTA MICROBIOL POL, V27, P111

[5]

Estavoyer J M, 1976, Pediatrie, V31, P295

[6] ANTIVIRAL AGENTS - 5H-AS-TRIAZINO[5,6-B]INDOLES [J].

GLADYCH, JMZ ;

STEWART, RC ;

STANFIELD, FJ ;

BOYLE, JJ ;

HORNBY, R ;

HAFF, RF ;

FERLAUTO, RJ ;

JACK, D ;

HUNT, JH ;

KORMENDY, CG .

JOURNAL OF MEDICINAL CHEMISTRY, 1972, 15 (03) :277-+

[7]

LUCKASOBSTEL B, 1973, ACTA MICROBIOL POL, V5, P197

[8]

LUM GS, 1957, J PHARMACOL EXP THER, V119, P284

[9]

MCLEAN DM, 1976, 3RD C ANT SUBST NEW

[10]

SIDWELL RW, 1974, 8TH P INT C CHEM PRO, P889

← 1 2 →