INFLUENCE OF TIDAL VOLUME ON HISTAMINE-INDUCED BRONCHOCONSTRICTION IN GUINEA-PIGS

被引：5

作者：

BENICHOU, M ^{[1
]}

LORINO, AM ^{[1
]}

LORINO, H ^{[1
]}

MACQUINMAVIER, I ^{[1
]}

ISTIN, N ^{[1
]}

HARF, A ^{[1
]}

机构：

[1] HOP HENRI MONDOR,INSERM,U296,DEPT PHARMACOL CLIN,F-94010 CRETEIL,FRANCE

来源：

JOURNAL OF APPLIED PHYSIOLOGY | 1990年 / 68卷 / 04期

关键词：

bronchopulmonary reactivity; respiratory compliance; respiratory conductance;

D O I：

10.1152/jappl.1990.68.4.1634

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The effects of tidal volume amplitude on bronchopulmonary reactivity were investigated in three groups of 14 anesthetized paralyzed mechanically ventilated guinea pigs. Animals of group 1 served as control; in animals of group 2, both the sympathetic and parasympathetic nervous systems were blocked; in animals of group 3, only the parasympathetic system was blocked. In each group, the animals were randomly divided into two subgroups characterized by their ventilatory pattern: rate of 60/min with a 6-ml/kg tidal volume or rate of 40/min with a 9-ml/kg tidal volume. Bronchopulmonary reactivity to infused histamine was assessed by the respiratory compliance and conductance values measured during bronchoconstriction and expressed as a percentage of the corresponding basal values. In group 1 the animals ventilated with a 9-ml/kg tidal volume were found significantly less reactive than those ventilated with a 6-ml/kg tidal volume. This difference was abolished in groups 2 and 3. These results demonstrate that the effects of increased tidal volume on bronchopulmonary reactivity are vagally mediated and suggest that the decrease observed in histamine-induced bronchoconstriction is mainly due to reflex effects evoked by stretch receptor stimulation.

引用

页码：1634 / 1639

页数：6