MICRONUCLEI IN CYTOKINESIS-BLOCKED LYMPHOCYTES OF CANCER-PATIENTS FOLLOWING FRACTIONATED PARTIAL-BODY RADIOTHERAPY

被引：115

作者：

FENECH, M

DENHAM, J

FRANCIS, W

MORLEY, A

机构：

[1] NEWCASTLE MATER HOSP, DEPT RADIAT ONCOL, WARATH, NSW 2298, AUSTRALIA

[2] ROYAL ADELAIDE HOSP, DEPT RADIOTHERAPY, ADELAIDE, SA 5000, AUSTRALIA

[3] FLINDERS UNIV, MED CTR, DEPT HAEMATOL, BEDFORD PK, SA 5042, AUSTRALIA

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1990年 / 57卷 / 02期

关键词：

D O I：

10.1080/09553009014552471

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We applied the cytokinesis-block micronucleus assay to measure chromosome damage in lymphocytes of 11 cancer patients undergoing fractionated partial-body irradiation. Measurements performed before, during and after cessation of radiotherapy showed a dose-related increase in micronucleus frequency in each of the patients studied. When the results for micronucleus frequency (Y) were plotted against the estimated equivalent whole-body dose (X) the dose-response relationship obtained was Y = 75·8X + 49·5 (r = 0·783, P < 0·0001). A general decline in MN frequency was observed during the post-treatment period down to 57 per cent (± 10) after 12 months but there was considerable variation between individuals. The advantages and disadvantages of the application of the cytokinesis-block micronucleus assay as a biological dosemeter for lymphocytes irradiated in vivo are discussed. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：373 / 383

页数：11

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