Chiral zirconium quantum dots: A new class of nanocrystals for optical detection of coronavirus

被引：65

作者：

Ahmed, Syed Rahin ^{[1
]}

Kang, Seon Woo ^{[2
]}

Oh, Sangjin ^{[2
]}

Lee, Jaebeom ^{[2
]}

Neethirajan, Suresh ^{[1
]}

机构：

[1] Univ Guelph, Sch Engn, BioNano Lab, Guelph, ON N1G 2W1, Canada

[2] Pusan Natl Univ, Dept Cognomechatron, Busan 609735, South Korea

来源：

HELIYON | 2018年 / 4卷 / 08期

基金：

加拿大自然科学与工程研究理事会; 新加坡国家研究基金会;

关键词：

Nanotechnology; Materials chemistry; Materials science; Biomedical engineering;

D O I：

10.1016/j.heliyon.2018.e00766

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A synthetic way of chiral zirconium quantum dots (Zr QDs) was presented for the first time using L(+)-ascorbic acid acts as a surface as well as chiral ligands. Different spectroscopic and microscopic analysis was performed for thorough characterization of Zr QDs. As-synthesized QDs exhibited fluorescence and circular dichroism properties, and the peaks were located at 412 nm and 352 nm, respectively. MTT assay was performed to test the cytotoxicity of the synthesized Zr QDs against rat brain glioma C6 cells. Synthesized QDs was further conjugated with anti-infectious bronchitis virus (IBV) antibodies of coronavirus to form an immunolink at the presence of the target analyte and anti-IBV antibody-conjugated magneto-plasmonic nanoparticles (MPNPs). The fluorescence properties of immuno-conjugated QD-MP NPs nanohybrids through separation by an external magnetic field enabled biosensing of coronavirus with a limit of detection of 79.15 EID/50 mu L.

引用

页数：17

共 43 条

[1] Optoelectronic fowl adenovirus detection based on local electric field enhancement on graphene quantum dots and gold nanobundle hybrid [J].

Ahmed, Syed Rahin ;

Mogus, Jack ;

Chand, Rohit ;

Nagy, Eva ;

Neethirajan, Suresh .

BIOSENSORS & BIOELECTRONICS, 2018, 103 :45-53

[2] Self-assembled star-shaped chiroplasmonic gold nanoparticles for an ultrasensitive chiro-immunosensor for viruses [J].

Ahmed, Syed Rahin ;

Nagy, Eva ;

Neethirajan, Suresh .

RSC ADVANCES, 2017, 7 (65) :40849-40857

[3] Formation of self-organized Zircaloy-4 oxide nanotubes in organic viscous electrolyte via anodization [J].

Ali, Ghafar ;

Park, Yang Jeong ;

Kim, Hyun Jin ;

Cho, Sung Oh .

NANOSCALE RESEARCH LETTERS, 2014, 9

[4] On the deposition mechanisms and the formation of glassy Cu-Zr thin films [J].

Almyras, G. A. ;

Matenoglou, G. M. ;

Komninou, Ph. ;

Kosmidis, C. ;

Patsalas, P. ;

Evangelakis, G. A. .

JOURNAL OF APPLIED PHYSICS, 2010, 107 (08)

[5] Giant Optical Activity of Quantum Dots, Rods, and Disks with Screw Dislocations [J].

Baimuratov, Anvar S. ;

Rukhlenko, Ivan D. ;

Noskov, Roman E. ;

Ginzburg, Pavel ;

Gun'ko, Yurii K. ;

Baranov, Alexander V. ;

Fedorov, Anatoly V. .

SCIENTIFIC REPORTS, 2015, 5

[6] Valence-Band and Chemical-State Analyses of Zr and O in Thermally Grown Thin Zirconium-Oxide Films: An XPS Study [J].

Bakradze, Georgijs ;

Jeurgens, Lars P. H. ;

Mittemeijer, Eric J. .

JOURNAL OF PHYSICAL CHEMISTRY C, 2011, 115 (40) :19841-19848

[7]

Chen O, 2013, NAT MATER, V12, P445, DOI [10.1038/NMAT3539, 10.1038/nmat3539]

[8] Modeling on the size dependent properties of InP quantum dots: a hybrid functional study [J].

Cho, Eunseog ;

Jang, Hyosook ;

Lee, Junho ;

Jang, Eunjoo .

NANOTECHNOLOGY, 2013, 24 (21)

[9] Living Yeast Cells as a Controllable Biosynthesizer for Fluorescent Quantum Dots [J].

Cui, Ran ;

Liu, Hui-Hui ;

Xie, Hai-Yan ;

Zhang, Zhi-Ling ;

Yang, Yi-Ran ;

Pang, Dai-Wen ;

Xie, Zhi-Xiong ;

Chen, Bei-Bei ;

Hu, Bin ;

Shen, Ping .

ADVANCED FUNCTIONAL MATERIALS, 2009, 19 (15) :2359-2364

[10] A new and straightforward synthesis route for preparing Cds quantum Dots [J].

de Azevedo, W. M. ;

Menezes, F. D. .

JOURNAL OF LUMINESCENCE, 2012, 132 (07) :1740-1743

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