Chiral zirconium quantum dots: A new class of nanocrystals for optical detection of coronavirus

被引：62

作者：

Ahmed, Syed Rahin ^{[1
]}

Kang, Seon Woo ^{[2
]}

Oh, Sangjin ^{[2
]}

Lee, Jaebeom ^{[2
]}

Neethirajan, Suresh ^{[1
]}

机构：

[1] Univ Guelph, Sch Engn, BioNano Lab, Guelph, ON N1G 2W1, Canada

[2] Pusan Natl Univ, Dept Cognomechatron, Busan 609735, South Korea

来源：

HELIYON | 2018年 / 4卷 / 08期

基金：

新加坡国家研究基金会; 加拿大自然科学与工程研究理事会;

关键词：

Nanotechnology; Materials chemistry; Materials science; Biomedical engineering;

D O I：

10.1016/j.heliyon.2018.e00766

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A synthetic way of chiral zirconium quantum dots (Zr QDs) was presented for the first time using L(+)-ascorbic acid acts as a surface as well as chiral ligands. Different spectroscopic and microscopic analysis was performed for thorough characterization of Zr QDs. As-synthesized QDs exhibited fluorescence and circular dichroism properties, and the peaks were located at 412 nm and 352 nm, respectively. MTT assay was performed to test the cytotoxicity of the synthesized Zr QDs against rat brain glioma C6 cells. Synthesized QDs was further conjugated with anti-infectious bronchitis virus (IBV) antibodies of coronavirus to form an immunolink at the presence of the target analyte and anti-IBV antibody-conjugated magneto-plasmonic nanoparticles (MPNPs). The fluorescence properties of immuno-conjugated QD-MP NPs nanohybrids through separation by an external magnetic field enabled biosensing of coronavirus with a limit of detection of 79.15 EID/50 mu L.

引用

页数：17

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