ATYPICAL LYMPHOCYTES IN SCHIZOPHRENIA

被引：4

作者：

LAHDELMA, RL

KATILA, H

HIRATAHIBI, M

ANDERSSON, L

APPELBERG, B

RIMON, R

机构：

[1] Department of Psychiatry, University of Helsinki

[2] Department of Pathology, University of Helsinki, Helsinki

[3] Department of Pathology, Okayama University Dental School, Okayama

来源：

EUROPEAN PSYCHIATRY | 1995年 / 10卷 / 02期

关键词：

SCHIZOPHRENIA; ATYPICAL LYMPHOCYTES; CELL SIZES;

D O I：

10.1016/0924-9338(96)80319-1

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Blood was drawn from 18 inpatients fullfilling the DSMIII criteria for schizophrenia and their 15 age- and sex-matched clinically infection-free controls before and after neuroleptic treatment. Blood films were stained with MGG solution, mixed, and subsequently read in random order by one observer. The lymphocytes were examined by light microscopy and classified into six types: normal lymphocytes, Downey type I atypical lymphocytes, Downey type Ill atypical lymphocytes, stress lymphocytes, plasmocytoid lymphocytes, and large granular lymphocytes. Downey type I and III atypical lymphocytes were classified into small, medium, and large lymphocytes. Schizophrenic patients had significantly more Downey type III medium size cells before treatment (p = 0.019 before treatment and p = 0.056 after treatment) and less Downey type I small size cells (p = 0.113 before treatment and p = 0.026 after treatment). Our study supports the idea of a possible subgroup of schizophrenia exhibiting immunological aberrations. In the present study, we found morphologically more specified cells which could be involved in this alteration.

引用

页码：92 / 96

页数：5

共 19 条

[1] American Psychiatric Association, DSMIII: Diagnostic and Statistical Manual of Mental Disorders, (1980)
[2] Asberg, Montgomery, Perris, Schalling, Sedvall, A Comprehensive Psychopathological Rating Scale, Acta Psychiatrica Scandinavica, 271, pp. 5-27, (1978)
[3] DeLisi, Goodman, Neckers, Wyatt, Lymphocyte subpopulations in chronic schizophrenic patients, Biol Psychiatry, 17, pp. 1003-1010, (1982)
[4] DeLisi, Crow, Is schizophrenia a viral or immunological disorder?, Psychiatr Clin North Am, 9, pp. 115-132, (1986)
[5] Ehrnst, Wiesel, Bjerkenstedt, Tribukait, Jonsson, Failure to detect immunologic stigmata in schizophrenia, Neuropsychobiology, 8, pp. 169-171, (1982)
[6] Fessel, Hirata-Hibi, Abnormal lymphocytes in schizophrenia, Archives of General Psychiatry, 9, pp. 601-613, (1963)
[7] Fessel, Hirata-Hibi, Shapiro, Genetic and stress factors affecting the abnormal lymphocyte in schizophreniaJ, Psychiatr Res, 3, pp. 275-283, (1965)
[8] Fieve, Blumenthal, Little, The relationship of atypical lymphocytes, phenothiazine and schizophrenia, Arch Gen Psychiatry, 15, pp. 529-534, (1966)
[9] Hirata-Hibi, Higashi, Tachibana, Watanabe, Stimulated lymphocytes in schizophrenia, Arch Gen Psychiatry, 39, pp. 82-87, (1982)
[10] Hirata-Hibi, Oh, Miyauchi, Tachibana, Evidence of lymphocyte abnormality in schizophrenia, Viruses, Immunity, and Mental Disorders, pp. 327-340, (1987)

← 1 2 →