THE EFFECTS OF CLONIDINE ON CARDIOVASCULAR-RESPONSES TO STANDING IN HEALTHY-VOLUNTEERS

被引:23
作者
COUPLAND, NJ [1 ]
BAILEY, JE [1 ]
WILSON, SJ [1 ]
HORVATH, R [1 ]
NUTT, D [1 ]
机构
[1] UNIV BRISTOL,PSYCHOPHARMACOL UNIT,BRISTOL BS8 1TD,AVON,ENGLAND
关键词
CLONIDINE; SYMPATHETIC NERVOUS SYSTEM; BLOOD PRESSURE MONITORING; HYPOTENSION;
D O I
10.1007/BF01826201
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
This study assessed the effects of clonidine on blood pressure (BP) and heart rare responses to active standing, recorded continuously using a Finapres monitor. Ten subjects were given a placebo infusion over 1 h, followed by clonidine hydrochloride 1.5 mu g/kg over 2 h. During placebo and at 1, 3 and 19 h following the clonidine infusion, heart rate and blood pressure were recorded during the second half of supine rest for 10 min, active standing and quiet standing for 7 min. Clonidine did not alter the size of immediate drop in BP on standing, although the nadir was lower. BP recovery was impaired, with a loss of the usual BP overshoot in most subjects and with delays in reaching supine levels of diastolic BP (6.1 versus 9.6 s; p < 0.01) and systolic BP (8.1 versus 12.3 s; p < 0.05). The compensatory initial heart rare rise was significantly increased from 47 to 53 beats/min (p < 0.05), athough the peak rate reached was reduced from 114 to 104 beats/min (p < 0.05). These results demonstrate that impairment of central sympathetic vasomotor drive leads to a delay in BP recovery and loss of initial BP overshoot immediately after standing, together with impaired maintenance of early steady-state BP.
引用
收藏
页码:171 / 177
页数:7
相关论文
共 50 条
[41]   THE EFFECTS OF CLONIDINE, GUANFACINE AND PHENYLEPHRINE ON THE EXCITATORY AND INHIBITORY RESPONSES OF THE RAT ANOCOCCYGEUS MUSCLE [J].
UZBAY, IT ;
ONUR, R .
ARCHIVES INTERNATIONALES DE PHYSIOLOGIE DE BIOCHIMIE ET DE BIOPHYSIQUE, 1993, 101 (06) :361-365
[42]   EFFECTS OF THYROID-HORMONE STATUS ON THE GROWTH-HORMONE RESPONSES TO CLONIDINE [J].
VELARDO, A ;
ZIZZO, G ;
DELLACASA, L ;
COLETTA, F ;
PANTALEONI, M ;
MARRAMA, P ;
DELRIO, G .
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY, 1993, 101 (04) :243-248
[43]   Comparison of pulpal anesthesia and cardiovascular parameters with lidocaine with epinephrine and lidocaine with clonidine after maxillary infiltration in type 2 diabetic volunteers [J].
Marija S. Milic ;
Bozidar Brkovic ;
Elena Krsljak ;
Dragica Stojic .
Clinical Oral Investigations, 2016, 20 :1283-1293
[44]   Effects of topical combinations of clonidine and pentoxifylline on capsaicin-induced allodynia and postcapsaicin tourniquet-induced pain in healthy volunteers: a double-blind, randomized, controlled study [J].
Ragavendran, J. Vaigunda ;
Laferriere, Andre ;
Bennett, Gary J. ;
Ware, Mark A. ;
Gandhi, Wiebke ;
Bley, Keith ;
Schweinhardt, Petra ;
Coderre, Terence J. .
PAIN, 2016, 157 (10) :2366-2374
[45]   Cardiovascular dynamics in healthy subjects with differing heart rate responses to tilt [J].
Ramirez-Marrero, Farah A. ;
Charkoudian, Nisha ;
Hart, Emma C. ;
Schroeder, Darrell ;
Zhong, Liu ;
Eisenach, John H. ;
Joyner, Michael J. .
JOURNAL OF APPLIED PHYSIOLOGY, 2008, 105 (05) :1448-1453
[46]   Oral clonidine inhibits visceral pain-related viscerosomatic and cardiovascular responses to colorectal distension in rats [J].
Brusberg, Mikael ;
Ravnefjord, Anna ;
Lindgreen, Magnus ;
Larsson, Hakan ;
Lindstrom, Erik ;
Martinez, Vicente .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2008, 591 (1-3) :243-251
[47]   Analgesic and sympatholytic effects of low-dose intrathecal clonidine compared with bupivacaine: a doseresponse study in female volunteers [J].
Ginosar, Y. ;
Riley, E. T. ;
Angst, M. S. .
BRITISH JOURNAL OF ANAESTHESIA, 2013, 111 (02) :256-+
[48]   Lack of sedative effects after vespertine intake of oxazepam as hypnotic in healthy volunteers [J].
Wilhelm, Barbara ;
Kellert, Renate ;
Schnell, Rainer ;
Luedtke, Holger ;
Petrini, Orlando .
PSYCHOPHARMACOLOGY, 2009, 205 (04) :679-688
[49]   EFFECTS OF INTRAMUSCULAR CLONIDINE ON HEMODYNAMIC AND PLASMA BETA-ENDORPHIN RESPONSES TO GYNECOLOGIC LAPAROSCOPY [J].
AHO, M ;
LEHTINEN, AM ;
LAATIKAINEN, T ;
KORTTILA, K .
ANESTHESIOLOGY, 1990, 72 (05) :797-802
[50]   Clonidine effects on protein and carbohydrate electrophysiological responses of labellar and tarsal sensilla in Phormia regina [J].
Masala, C. ;
Solari, P. ;
Sollai, G. ;
Crnjar, R. ;
Liscia, A. .
JOURNAL OF INSECT PHYSIOLOGY, 2008, 54 (07) :1193-1199