A SINGLE VH GENE SEGMENT ENCODES THE IMMUNE-RESPONSE TO PHOSPHORYLCHOLINE - SOMATIC MUTATION IS CORRELATED WITH THE CLASS OF THE ANTIBODY

被引：544
作者：
CREWS, S
GRIFFIN, J
HUANG, H
CALAME, K
HOOD, L
机构：
[1] UNIV CALIF LOS ANGELES,DEPT BIOL CHEM,LOS ANGELES,CA 90024
[2] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,LOS ANGELES,CA 90024
来源：
CELL | 1981年 / 25卷 / 01期
关键词：
D O I：
10.1016/0092-8674(81)90231-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：59 / 66
页数：8
相关论文
共 37 条
[1]   IS TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE A SOMATIC MUTAGEN IN LYMPHOCYTES [J].
BALTIMORE, D .
NATURE, 1974, 248 (5447) :409-411
[2]   MOUSE IMMUNOGLOBULIN HEAVY-CHAINS ARE CODED BY MULTIPLE GERM LINE VARIABLE REGION GENES [J].
BARSTAD, P ;
FARNSWORTH, V ;
WEIGERT, M ;
COHN, M ;
HOOD, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (10) :4096-4100
[3]   IMMUNOGLOBULINS WITH HAPTEN-BINDING ACTIVITY - STRUCTURE-FUNCTION CORRELATIONS AND GENETIC IMPLICATIONS [J].
BARSTAD, P ;
HUBERT, J ;
HUNKAPILLER, M ;
GOETZE, A ;
SCHILLING, J ;
BLACK, B ;
EATON, B ;
RICHARDS, J ;
WEIGERT, M ;
HOOD, L .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1978, 8 (07) :497-503
[4]   SCREENING GAMMAGT RECOMBINANT CLONES BY HYBRIDIZATION TO SINGLE PLAQUES INSITU [J].
BENTON, WD ;
DAVIS, RW .
SCIENCE, 1977, 196 (4286) :180-182
[5]   SEQUENCES OF MOUSE IMMUNOGLOBULIN LIGHT CHAIN GENES BEFORE AND AFTER SOMATIC CHANGES [J].
BERNARD, O ;
HOZUMI, N ;
TONEGAWA, S .
CELL, 1978, 15 (04) :1133-1144
[6]   COMPLETE IMMUNOGLOBULIN GENE IS CREATED BY SOMATIC RECOMBINATION [J].
BRACK, C ;
HIRAMA, M ;
LENHARDSCHULLER, R ;
TONEGAWA, S .
CELL, 1978, 15 (01) :1-14
[7]   ORIGIN OF ANTIBODY VARIATION [J].
BRENNER, S ;
MILSTEIN, C .
NATURE, 1966, 211 (5046) :242-&
[8]  
CHANG SP, 1981, J IMMUNOL, V126, P975
[9]  
Cohn M, 1974, IMMUNE SYSTEM GENES, P89
[10]   DELETIONS ARE ASSOCIATED WITH SOMATIC REARRANGEMENT OF IMMUNOGLOBULIN HEAVY-CHAIN GENES [J].
CORY, S ;
ADAMS, JM .
CELL, 1980, 19 (01) :37-51
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