PHOSPHATIDYLINOSITOL 3-KINASE INHIBITION DURING PLATELET ACTIVATION BY THE THROMBIN RECEPTOR ACTIVATING PEPTIDE PREVENTS SUSTAINED EXPOSURE OF GPIIB-IIIA AND IRREVERSIBLE AGGREGATION, BUT NOT ACTIN ASSEMBLY

被引：0
|
作者：
KOVACSOVICS, TJ
TOKER, A
CANTLEY, LC
HARTWIG, JH
机构：
[1] BRIGHAM & WOMENS HOSP,DIV EXPTL MED,BOSTON,MA 02115
[2] BRIGHAM & WOMENS HOSP,DIV HEMATOL ONCOL,BOSTON,MA 02115
[3] HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,DIV SIGNAL TRANSDUCT,BOSTON,MA 02215
来源：
BLOOD | 1994年 / 84卷 / 10期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：A533 / A533
页数：1
相关论文
共 7 条
  • [1] PHOSPHOINOSITIDE 3-KINASE INHIBITION SPARES ACTIN ASSEMBLY IN ACTIVATING PLATELETS BUT REVERSES PLATELET-AGGREGATION
    KOVACSOVICS, TJ
    BACHELOT, C
    TOKER, A
    VLAHOS, CJ
    DUCKWORTH, B
    CANTLEY, LC
    HARTWIG, JH
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (19) : 11358 - 11366
  • [2] A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase
    Trumel, C
    Payrastre, B
    Plantavid, M
    Hechler, B
    Viala, C
    Presek, P
    Martinson, EA
    Cazenave, JP
    Chap, H
    Gachet, C
    BLOOD, 1999, 94 (12) : 4156 - 4165
  • [3] THE EFFECT OF THROMBIN RECEPTOR ACTIVATING PEPTIDE ON PLATELET-AGGREGATION IN PATIENTS UNDERGOING GLYCOPROTEIN IIB/IIIA RECEPTOR BLOCKADE WITH 7E3
    KLEIMAN, NS
    JORDAN, R
    COLLER, B
    NORTON, D
    WEISMAN, H
    MERCADO, C
    ROSE, D
    TRAINOR, K
    JOHNSON, S
    BUSCHMANN, L
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1994, : A63 - A63
  • [4] DIFFERENTIAL INHIBITION OF PLATELET-AGGREGATION INDUCED BY ADENOSINE-DIPHOSPHATE OR A THROMBIN RECEPTOR-ACTIVATING PEPTIDE IN PATIENTS TREATED WITH BOLUS CHIMERIC 7E3 FAB - IMPLICATIONS FOR INHIBITION OF THE INTERNAL POOL OF GPIIB/IIIA RECEPTORS
    KLEIMAN, NS
    RAIZNER, AE
    JORDAN, R
    WANG, AL
    NORTON, D
    MACE, KF
    JOSHI, A
    COLLER, BS
    WEISMAN, HF
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1995, 26 (07) : 1665 - 1671
  • [5] Glucagon-like peptide-2 receptor activation engages bad and glycogen synthase kinase-3 in a protein kinase A-dependent manner and prevents apoptosis following inhibition of phosphatidylinositol 3-kinase
    Yusta, B
    Estall, J
    Drucker, DJ
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (28) : 24896 - 24906
  • [6] Differential inhibition of adenosine diphosphate-versus thrombin receptor-activating peptide-stimulated platelet fibrinogen binding by abciximab due to different glycoprotein IIb/IIIa activation kinetics
    Weber, AA
    Schrör, K
    BLOOD, 2001, 98 (05) : 1619 - 1621
  • [7] PLATELET-AGGREGATION AND FIBRINOGEN BINDING IN HUMAN, RHESUS-MONKEY, GUINEA-PIG, HAMSTER AND RAT-BLOOD - ACTIVATION BY ADP AND A THROMBIN RECEPTOR PEPTIDE AND INHIBITION BY GLYCOPROTEIN-IIB/IIIA ANTAGONISTS
    COOK, NS
    ZERWES, HG
    TAPPARELLI, C
    POWLING, M
    SINGH, J
    METTERNICH, R
    HAGENBACH, A
    THROMBOSIS AND HAEMOSTASIS, 1993, 70 (03) : 531 - 539
1