ULTRA-LONG-DURATION LOCAL-ANESTHESIA PRODUCED BY INJECTION OF LECITHIN-COATED TETRACAINE MICROCRYSTALS

被引:32
作者
BOEDEKER, BH [1 ]
LOJESKI, EW [1 ]
KLINE, MD [1 ]
HAYNES, DH [1 ]
机构
[1] WALTER REED ARMY MED CTR,DEPT ANESTHESIOL,WASHINGTON,DC 20307
关键词
D O I
10.1002/j.1552-4604.1994.tb02026.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This study was designed to determine if microencapsulated tetracaine would provide a longer duration of local anesthesia than nonmicroencapsulated (neat) tetracaine. Local anesthesia was determined by monitoring the response of the rat to tail clamping after the installation of a subcutaneous ring block. Ten percent microencapsulated tetracaine was found to provide local anesthesia of the tail for a 43-hour duration. Ten percent tetracaine solution was toxic. One percent tetracaine solution provided a tail block lasting 8 hours. Lecithin membranes without drug provided no block. This study demonstrates that lecithin-coated tetracaine microcrystals produce a local anesthetic effect that is ultra-long in duration, reversible, and not systemically toxic.
引用
收藏
页码:699 / 702
页数:4
相关论文
共 6 条
[1]   AFFERENT AND EFFERENT CONNECTIONS OF THE RAT TAIL FLICK REFLEX (A MODEL USED TO ANALYZE PAIN CONTROL MECHANISMS) [J].
GROSSMAN, ML ;
BASBAUM, AI ;
FIELDS, HL .
JOURNAL OF COMPARATIVE NEUROLOGY, 1982, 206 (01) :9-16
[2]   ULTRA-LONG-DURATION LOCAL-ANESTHESIA PRODUCED BY INJECTION OF LECITHIN-COATED METHOXYFLURANE MICRODROPLETS [J].
HAYNES, DH ;
KIRKPATRICK, AF .
ANESTHESIOLOGY, 1985, 63 (05) :490-499
[3]  
HAYNES DH, 1987, P INT S CONTROLLED R, V14, P293
[4]  
KIRKPATRICK AF, 1991, REGION ANESTH, V16, P164
[5]   DRUG DELIVERY SYSTEMS .1. SITE-SPECIFIC DRUG DELIVERY USING LIPOSOMES AS CARRIERS [J].
RANADE, VV .
JOURNAL OF CLINICAL PHARMACOLOGY, 1989, 29 (08) :685-694
[6]   PHARMACOKINETICS OF METHOXYFLURANE AFTER ITS INTRA-DERMAL INJECTION AS LECITHIN-COATED MICRODROPLETS [J].
WU, MY ;
JOHANSSON, J ;
ALTMAN, NH ;
HAYNES, DH ;
FISEROVABERGEROVA, V .
JOURNAL OF CONTROLLED RELEASE, 1989, 9 (01) :1-12