EFFECT OF ORALLY-ADMINISTERED MONOCLONAL-ANTIBODY ON PERSISTENT CRYPTOSPORIDIUM-PARVUM INFECTION IN SCID MICE

被引：28
|
作者：
PERRYMAN, LE
KEGERREIS, KA
MASON, PH
机构：
来源：
INFECTION AND IMMUNITY | 1993年 / 61卷 / 11期
关键词：
D O I：
10.1128/IAI.61.11.4906-4908.1993
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
scid mice, persistently infected after exposure to 10(7) Cryptosporidium parvum oocysts, were treated daily for 14 to 17 days with 0.4 mg of monoclonal antibody (mAb) 17.41 administered by the oral route. Mice receiving mAb 17.41 shed significantly fewer (P < 0.005) C. parvum oocysts than scid mice receiving isotype control mAb. Intestinal (but not gastric) infectivity scores were also reduced for scid mice treated with mAb 17.41 (P < 0.01).
引用
收藏
页码：4906 / 4908
页数：3
相关论文
共 50 条
  • [1] EFFECTS OF IMMUNE COLOSTRUM AND ORALLY-ADMINISTERED ANTISPOROZOITE MONOCLONAL-ANTIBODIES ON THE OUTCOME OF CRYPTOSPORIDIUM-PARVUM INFECTIONS IN NEONATAL MICE
    ARROWOOD, MJ
    MEAD, JR
    MAHRT, JL
    STERLING, CR
    INFECTION AND IMMUNITY, 1989, 57 (08) : 2283 - 2288
  • [2] MONOCLONAL-ANTIBODY IMMUNOTHERAPY IN NUDE-MICE PERSISTENTLY INFECTED WITH CRYPTOSPORIDIUM-PARVUM
    BJORNEBY, JM
    HUNSAKER, BD
    RIGGS, MW
    PERRYMAN, LE
    INFECTION AND IMMUNITY, 1991, 59 (03) : 1172 - 1176
  • [3] EFFECT OF SPLEEN-CELL POPULATIONS ON RESOLUTION OF CRYPTOSPORIDIUM-PARVUM INFECTION IN SCID MICE
    PERRYMAN, LE
    MASON, PH
    CHRISP, CE
    INFECTION AND IMMUNITY, 1994, 62 (04) : 1474 - 1477
  • [4] Effect of egg yolk antibody on experimental Cryptosporidium parvum infection in scid mice
    Kobayashi, C
    Yokoyama, H
    Nguyen, SV
    Kodama, Y
    Kimata, TB
    Izeki, M
    VACCINE, 2004, 23 (02) : 232 - 235
  • [5] MECHANISMS OF INNATE AND ACQUIRED-RESISTANCE TO CRYPTOSPORIDIUM-PARVUM INFECTION IN SCID MICE
    MCDONALD, V
    BANCROFT, GJ
    PARASITE IMMUNOLOGY, 1994, 16 (06) : 315 - 320
  • [6] BOVINE ANTIBODY AGAINST CRYPTOSPORIDIUM-PARVUM ELICITS A CIRCUMSPOROZOITE PRECIPITATE-LIKE REACTION AND HAS IMMUNOTHERAPEUTIC EFFECT AGAINST PERSISTENT CRYPTOSPORIDIOSIS IN SCID MICE
    RIGGS, MW
    CAMA, VA
    LEARY, HL
    STERLING, CR
    INFECTION AND IMMUNITY, 1994, 62 (05) : 1927 - 1939
  • [7] EFFECTS OF COLOSTRAL ANTIBODY ON SUSCEPTIBILITY OF CALVES TO CRYPTOSPORIDIUM-PARVUM INFECTION
    HARP, JA
    WOODMANSEE, DB
    MOON, HW
    AMERICAN JOURNAL OF VETERINARY RESEARCH, 1989, 50 (12) : 2117 - 2119
  • [8] IMPORTANCE OF GAMMA-INTERFERON IN RESISTANCE OF SEVERE COMBINED IMMUNODEFICIENT (SCID) MICE TO INFECTION WITH CRYPTOSPORIDIUM-PARVUM
    HARP, JA
    CHEN, W
    HARMSEN, AG
    HAVELL, EA
    JOURNAL OF IMMUNOLOGY, 1993, 150 (08): : A67 - A67
  • [9] CHRONIC CRYPTOSPORIDIUM-PARVUM INFECTIONS IN CONGENITALLY IMMUNODEFICIENT SCID AND NUDE-MICE
    MEAD, JR
    ARROWOOD, MJ
    SIDWELL, RW
    HEALEY, MC
    JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (06): : 1297 - 1304
  • [10] DETECTION OF CRYPTOSPORIDIUM-PARVUM OOCYSTS IN BOVINE FECES BY MONOCLONAL-ANTIBODY CAPTURE ENZYME-LINKED-IMMUNOSORBENT-ASSAY
    ANUSZ, KZ
    MASON, PH
    RIGGS, MW
    PERRYMAN, LE
    JOURNAL OF CLINICAL MICROBIOLOGY, 1990, 28 (12) : 2770 - 2774
12345