EFFECT OF DIETARY NUCLEOTIDES ON THE FATTY-ACID COMPOSITION OF RAT-LIVER MICROSOMES

被引：5

作者：

NUNEZ, MC

AYUDARTE, MV

GIL, A

SUAREZ, MD

机构：

[1] UNIV GRANADA,DEPT RES UNIASA,GRANADA,SPAIN

[2] UNIV GRANADA,DEPT BIOCHEM & MOLEC BIOL,GRANADA,SPAIN

来源：

ARCHIVES INTERNATIONALES DE PHYSIOLOGIE DE BIOCHIMIE ET DE BIOPHYSIQUE | 1993年 / 101卷 / 02期

关键词：

DIETARY NUCLEOTIDES; FATTY ACIDS; LIVER MICROSOMES; DESATURASE ACTIVITY;

D O I：

10.3109/13813459309008880

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study was designed to evaluate the influence of dietary nucleotides on the lipid composition of liver microsomes in weanling rats. Rats at weaning were fed, one group with a semipurified nucleotide-free diet and three groups with the same diet supplemented with three different levels of each of the nucleotides AMP, GMP, IMP, UMP and CMP, during 4 weeks. Long chain polyunsaturated fatty acids of the n-6 and n-3 series were increased in phospholipids of liver microsomes for rats fed the nucleotide sypplemented diets; however, the cholesterol/phospholipid phosphorus ratio was maintained fairly constant. The results obtained suggest that dietary nucleotides modify the polyunsaturated fatty acid metabolism through a lower rat liver delta-9 desaturase activity and through increased activities of delta-5 and delta-4

引用

页码：123 / 128

页数：6

共 43 条

[1]

BARTLETT GR, 1959, J BIOL CHEM, V234, P466

[2]

BOZA J, 1991, IN PRESS J PARENT EN

[3]

BRENNER R R, 1981, Progress in Lipid Research, V20, P315, DOI 10.1016/0163-7827(81)90063-1

[4]

BRENNER R R, 1981, Progress in Lipid Research, V20, P41, DOI 10.1016/0163-7827(81)90012-6