GROWTH-HORMONE ACTIVATES MITOGEN-ACTIVATED PROTEIN-KINASE AND S6 KINASE AND PROMOTES INTRACELLULAR TYROSINE PHOSPHORYLATION IN 3T3-F442A PREADIPOCYTES

被引：88

作者：

ANDERSON, NG

机构：

[1] The Hannah Research Institute

来源：

BIOCHEMICAL JOURNAL | 1992年 / 284卷

关键词：

D O I：

10.1042/bj2840649

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Physiological concentrations of growth hormone induced a rapid and transient activation of mitogen-activated protein kinase (MAP kinase) and S6 kinase in 3T3-F442A preadipocytes. These effects were abrogated by staurosporine and in cells chronically pretreated with phorbol esters, suggesting that protein kinase C is involved in the mechanism of activation. In addition, three cytosolic proteins exhibited a growth-hormone-dependent increase in tyrosine phosphorylation.

引用

页码：649 / 652

页数：4