GROWTH-HORMONE ACTIVATES MITOGEN-ACTIVATED PROTEIN-KINASE AND S6 KINASE AND PROMOTES INTRACELLULAR TYROSINE PHOSPHORYLATION IN 3T3-F442A PREADIPOCYTES

被引：88
作者：
ANDERSON, NG
机构：
[1] The Hannah Research Institute
来源：
BIOCHEMICAL JOURNAL | 1992年 / 284卷
关键词：
D O I：
10.1042/bj2840649
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Physiological concentrations of growth hormone induced a rapid and transient activation of mitogen-activated protein kinase (MAP kinase) and S6 kinase in 3T3-F442A preadipocytes. These effects were abrogated by staurosporine and in cells chronically pretreated with phorbol esters, suggesting that protein kinase C is involved in the mechanism of activation. In addition, three cytosolic proteins exhibited a growth-hormone-dependent increase in tyrosine phosphorylation.
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页码：649 / 652
页数：4
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