LOCAL AGGREGATION OF HORMONE-RECEPTOR COMPLEXES IS REQUIRED FOR ACTIVATION BY EPIDERMAL GROWTH-FACTOR

被引：225

作者：

SCHECHTER, Y ^{[1
]}

HERNAEZ, L ^{[1
]}

SCHLESSINGER, J ^{[1
]}

CUATRECASAS, P ^{[1
]}

机构：

[1] WEIZMANN INST SCI, DEPT IMMUNOL, REHOVOT 76100, ISRAEL

来源：

NATURE | 1979年 / 278卷 / 5707期

关键词：

D O I：

10.1038/278835a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An analogue of epidermal growth factor (EGF) which is virtually devoid of biological activity retains receptor binding activity but cannot form cell surface clusters or patches. Bivalent anti-EGF antibodies restore both bioactivity and patch formation. The sensitivity of fibroblasts to native EGF can also be enhanced greatly by these antibodies, especially in hormone-resistant cell lines. © 1979 Nature Publishing Group.

引用

页码：835 / 838

页数：4

共 25 条

[1] MECHANISM OF ACTION OF CHOLERA TOXIN AND MOBILE RECEPTOR THEORY OF HORMONE RECEPTOR ADENYLATE CYCLASE INTERACTIONS [J].

BENNETT, V ;

OKEEFE, E ;

CUATRECASAS, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (01) :33-37

[2] I125 LABELED HUMAN EPIDERMAL GROWTH-FACTOR - BINDING, INTERNALIZATION, AND DEGRADATION IN HUMAN FIBROBLASTS [J].

CARPENTER, G ;

COHEN, S .

JOURNAL OF CELL BIOLOGY, 1976, 71 (01) :159-171

[3]

Cohen S, 1974, Recent Prog Horm Res, V30, P551

[4]

Cohen S, 1974, Recent Prog Horm Res, V30, P533

[5]

CUATRECASAS P, 1973, J BIOL CHEM, V248, P3528

[6] MEMBRANE RECEPTORS [J].

CUATRECASAS, P .

ANNUAL REVIEW OF BIOCHEMISTRY, 1974, 43 :169-214

[7]

GOSPODAROWICZ D, 1977, ENDOCRINOLOGY, V100, P1108

[8]

HOLLENBERG MD, 1975, J BIOL CHEM, V250, P3845

[9] EPIDERMAL GROWTH-FACTOR - RECEPTORS IN HUMAN FIBROBLASTS AND MODULATION OF ACTION BY CHOLERA TOXIN [J].

HOLLENBERG, MD ;

CUATRECASAS, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (10) :2964-2968

[10] ANTIBODIES TO PURIFIED INSULIN RECEPTOR HAVE INSULIN-LIKE ACTIVITY [J].

JACOBS, S ;

CHANG, KJ ;

CUATRECASAS, P .

SCIENCE, 1978, 200 (4347) :1283-1284

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