IRREVERSIBLE ENZYME INHIBITORS .172. PROTEOLYTIC ENZYMES .16. COVALENT BONDING OF SULFONYL FLUORIDE GROUP TO SERINE OUTSIDE ACTIVE SITE OF ALPHA-CHYMOTRYPSIN BY EXO-TYPE ACTIVE-SITE DIRECTED IRREVERSIBLE INHIBITORS

被引：12
作者：
CARDINAU.R
BAKER, BR
机构：
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1970年 / 13卷 / 03期
关键词：
D O I：
10.1021/jm00297a030
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
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页码：467 / &
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[1]   IRREVERSIBLE ENZYME INHIBITORS .105. DIFFERENTIAL IRREVERSIBLE INHIBITION OF VERTEBRATE DIHYDROFOLIC REDUCTASES BY DERIVATIVES OF 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-PHENYL-S-TRIAZINES SUBSTITUTED WITH A TERMINAL SULFONYL FLUORIDE [J].
BAKER, BR ;
LOURENS, GJ .
JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (06) :1113-+
[2]   IRREVERSIBLE ENZYME INHIBITORS .165. PROTEOLYTIC ENZYMES .15. INHIBITION OF GUINEA PIG COMPLEMENT BY DERIVATIVES OF M-PHENOXYPROPOXYBENZAMIDINE [J].
BAKER, BR ;
CORY, M .
JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (06) :1053-&
[3]   TISSUE-SPECIFIC IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE [J].
BAKER, BR .
ACCOUNTS OF CHEMICAL RESEARCH, 1969, 2 (05) :129-+
[4]   IRREVERSIBLE ENZYME INHIBITORS .125. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF XANTHINE OXIDASE DERIVED FROM ARYLPURINES AND PYRAZOLO[3,4-D]PYRIMIDINES BEARING A TERMINAL SULFONYL FLUORIDE [J].
BAKER, BR ;
KOZMA, JA .
JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (04) :656-&
[5]  
BAKER BR, 1970, J MED CHEM, V13, P461, DOI 10.1021/jm00297a029
[6]   IRREVERSIBLE ENZYME INHIBITORS . 144 . PROTEOLYTIC ENZYMES .7. ADDITIONAL ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF TRYPSIN DERIVED FROM M- AND P-(PHENOXYALKOXY)BENZAMIDINES WITH A TERMINAL SULFONYL FLUORIDE [J].
BAKER, BR ;
ERICKSON, EH .
JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (01) :112-&
[7]   IRREVERSIBLE ENZYME INHIBITORS .115. PROTEOLYTIC ENZYMES .5. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF TRYPSIN DERIVED FROM P-(PHENOXYALKOXY)BENZAMIDINES WITH A TERMINAL SULFONYL FLUORIDE [J].
BAKER, BR ;
ERICKSON, EH .
JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (02) :245-&
[8]   IRREVERSIBLE ENZYME INHIBITORS .150. PROTEOLYTIC ENZYMES .9. (3,4-DICHLOROPHENOXYACETAMIDO)PYRIDINES BRIDGED BY A QUATERNARY SALT TO A TERMINAL SULFONYL FLUORIDE . POTENT IRREVERSIBLE INHIBITORS OF ALPHA-CHYMOTRYPSIN [J].
BAKER, BR ;
HURLBUT, JA .
JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (02) :221-&
[9]   IRREVERSIBLE ENZYME INHIBITORS .145. PROTEOLYTIC ENZYMES .8. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF ALPHA-CHYMOTRYPSIN DERIVED FROM ALPHA-(2-CARBOXY-4-CHLOROPHENOXY)ACETAMIDE BEARING A TERMINAL SULFONYL FLUORIDE [J].
BAKER, BR ;
HURLBUT, JA .
JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (01) :118-&
[10]   IRREVERSIBLE ENZYME INHIBITORS .113. PROTEOLYTIC ENZYMES .3. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF ALPHA-CHYMOTRYPSIN DERIVED FROM PHENOXYACETAMIDES WITH AN N-FLUOROSULFONYLPHENYL SUBSTITUENT [J].
BAKER, BR ;
HURLBUT, JA .
JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (02) :233-&
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