RADIATION-THERAPY COMBINED WITH RADIOSENSITIZING AGENTS FOR CEREBRAL GLIOBLASTOMA IN ADULTS

被引:11
作者
MATSUTANI, M
NAKAMURA, O
NAKAMURA, M
NAGASHIMA, T
ASAI, A
FUJIMAKI, T
TANAKA, H
UEKI, K
TANAKA, Y
机构
[1] TOKYO METROPOLITAN KOMAGOME HOSP,DEPT NEUROSURG,TOKYO,JAPAN
[2] TOKYO METROPOLITAN KOMAGOME HOSP,DEPT RADIAT THERAPY,TOKYO,JAPAN
关键词
GLIOBLASTOMA; BRAIN TUMOR; RADIATION THERAPY; CHEMOTHERAPY; ACNU;
D O I
10.1007/BF01053276
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We analyzed our treatment results of 71 operated patients with cerebral glioblastoma treated by conventional external radiation therapy (mean dose 60.2 Gy) combined with radiosensitizing agents. More than 50% reduction of tumor volume was obtained in 20 patients (28.2%). A response rate of at least 40% was obtained in patients treated with combined ACNU-vincristine-nicardipine, ACNU-5FU-hydroxyurea, or cisplatin alone. The combination of ACNU and vincristine with or without nicardipine resulted in significantly longer survival. The median survival in this group was 101.1 weeks and the two-year survival rate was 45.9%; these results were significantly better than those achieved with other ACNU combinations or other combinations without ACNU. In the analysis of survival, factors correlated to longer survival were a patient age of younger than 45 years, wide resection of the tumor, a good postoperative performance status (KS greater than or equal to 70%), a radiation dose of 68-72 Gy, small postoperative tumor remnants (< 20 cm(3)), no visible tumor after radiation therapy, and the administration of adjuvant chemotherapy. Maximum resection of the tumor and localized irradiation with a dose of 70 Gy combined with ACNU and vincristine appears to be the most effective treatment at present.
引用
收藏
页码:227 / 237
页数:11
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