PRP GENOTYPE AND AGENT EFFECTS IN SCRAPIE - CHANGE IN ALLELIC INTERACTION WITH DIFFERENT ISOLATES OF AGENT IN SHEEP, A NATURAL HOST OF SCRAPIE

被引：411

作者：

GOLDMANN, W ^{[1
]}

HUNTER, N ^{[1
]}

SMITH, G ^{[1
]}

FOSTER, J ^{[1
]}

HOPE, J ^{[1
]}

机构：

[1] MRC, NEUROPATHOGENESIS UNIT, EDINBURGH EH9 3JF, MIDLOTHIAN, SCOTLAND

来源：

JOURNAL OF GENERAL VIROLOGY | 1994年 / 75卷

关键词：

D O I：

10.1099/0022-1317-75-5-989

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Man and sheep are the two species in which spongiform encephalopathies occur naturally, and in which there are recognized genetic components that predispose an individual person or sheep to clinical disease. In both species mutations/polymorphisms in the PrP gene have been linked to the incidence of natural disease, but only in sheep is it possible to investigate by deliberate exposure to infection whether these polymorphisms are directly correlated with survival time. Cheviot sheep of different PrP genotypes were challenged with one of two isolates of scrapie or an isolate of bovine spongiform encephalopathy and the survival time and incidence of disease were monitored. Genotype analysis showed that dimorphisms in codons 136 and 171 of the ovine PrP gene correlated with control of disease incidence and modulation of incubation time. Crucially, the functional effects of these domains of PrP were shown to alternate depending on the isolate of infecting agent.

引用

页码：989 / 995

页数：7

共 29 条

[1] AMINO-ACID POLYMORPHISM IN HUMAN PRION PROTEIN AND AGE AT DEATH IN INHERITED PRION DISEASE [J].

BAKER, HF ;

POULTER, M ;

CROW, TJ ;

FRITH, CD ;

LOFTHOUSE, R ;

RIDLEY, RM ;

COLLINGE, J .

LANCET, 1991, 337 (8752) :1286-1286

[2] GENERAL METHOD FOR ISOLATION OF HIGH MOLECULAR-WEIGHT DNA FROM EUKARYOTES [J].

BLIN, N ;

STAFFORD, DW .

NUCLEIC ACIDS RESEARCH, 1976, 3 (09) :2303-2308

[3]

BROWN P, 1992, REV NEUROL, V148, P317

[4] FRIENDLY FIRE IN MEDICINE - HORMONES, HOMOGRAFTS, AND CREUTZFELDT-JAKOB DISEASE [J].

BROWN, P ;

PREECE, MA ;

WILL, RG .

LANCET, 1992, 340 (8810) :24-27

[5] MICE DEVOID OF PRP ARE RESISTANT TO SCRAPIE [J].

BUELER, H ;

AGUZZI, A ;

SAILER, A ;

GREINER, RA ;

AUTENRIED, P ;

AGUET, M ;

WEISSMANN, C .

CELL, 1993, 73 (07) :1339-1347

[6] GENETIC PREDISPOSITION TO IATROGENIC CREUTZFELDT-JAKOB DISEASE [J].

COLLINGE, J ;

PALMER, MS ;

DRYDEN, AJ .

LANCET, 1991, 337 (8755) :1441-1442

[7]

Dickinson A. G., 1976, Slow virus diseases of animals and man,, P209

[8] SOME FACTORS CONTROLLING INCIDENCE OF SCRAPIE IN CHEVIOT SHEEP INJECTED WITH A CHEVIOT-PASSAGED SCRAPIE AGENT [J].

DICKINSON, AG ;

STAMP, JT ;

RENWICK, CC ;

RENNIE, JC .

JOURNAL OF COMPARATIVE PATHOLOGY, 1968, 78 (03) :313-+

[9]

DICKINSON AG, 1988, CIBA F SYMP, V135, P63

[10]

FARRER LA, 1993, AM J HUM GENET, V53, P125

← 1 2 3 →