EFFECT OF ANGIOTENSIN-II AND THROMBOXANE A2 ON THE PRODUCTION OF MATRIX METALLOPROTEINASE BY HUMAN AORTIC SMOOTH-MUSCLE CELLS

被引：0
|
作者：
TAKAGISHI, T
MURAHASHI, N
AZAGAMI, S
MORIMATSU, M
SASAGURI, Y
机构：
[1] UNIV OCCUPAT & ENVIRONM HLTH,DEPT PATHOL,KITAKYUSHU,FUKUOKA 807,JAPAN
[2] KURUME UNIV,SCH MED,DEPT PATHOL,KURUME,FUKUOKA 830,JAPAN
来源：
BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL | 1995年 / 35卷 / 02期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Angiotensin II (AGII) and thromboxane A(2) (TXA(2)), potent vasoconstrictors, augmented the production of the precursor of tissue procollagenase / promatrixmetalloproteinase-1 (proMMP-1) and DNA synthesis in cultured human aortic smooth muscle cells (SMC) significantly compared with that in untreated SMC. Moreover, AGII and TXA(2) stimulated hydrolysis of phosphoinositides and subsequent formation of inositol triphosphate (IP3), leading to an increase in the intracellular free Ca2+ concentration. These results suggest that the production of proMMP-1 increased by AGII and TXA(2) in intimal SMC in relation to cell proliferation plays a role in arterial reconstruction in vascular diseases.
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页码：265 / 273
页数：9
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