SIGNET-RING CELL CARCINOID - A PRIMARY HEPATIC CARCINOID-TUMOR WITH CYTOPLASMIC INCLUSIONS COMPRISING OF AGGREGATES OF KERATIN

被引：0

作者：

AOKI, K ^{[1
]}

SAKAMOTO, M ^{[1
]}

MUKAI, K ^{[1
]}

KOSUGE, T ^{[1
]}

TAKAYAMA, T ^{[1
]}

HIROHASHI, S ^{[1
]}

机构：

[1] NATL CANC CTR,RES INST,DIV PATHOL,1-1 TSUKIJI 5 CHOME,CHUO KU,TOKYO 104,JAPAN

来源：

JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 1992年 / 22卷 / 01期

关键词：

SIGNET-RING CELL CARCINOID; LIVER; INCLUSION; CYTOKERATIN;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A case of primary hepatic carcinoid tumor was recently encountered, which was argyrophil and showed positive reactions to serotonin, gastrin and pancreatic peptide in an immunohistochemical hormonal study. The tumor had unusual morphologic features. The neoplastic cells had a signet-ring cell appearance, similar to the signet-ring cells normally seen in mucin-producing adenocarcinoma. Ultrastructural and immunohistochemical studies revealed the formation of the signet-ring cells to have been caused by the presence of cytoplasmic inclusions consisting of cytokeratins. Further investigation, using eight monoclonal antibodies recognizing cytokeratins of different molecular weights, showed the accumulated cytokeratins to be of low and medium molecular weights. The morphologic observations in this unusual case of hepatic carcinoid tumor are described and reported cases with similar features, for which we propose the term "signet-ring cell carcinoid," are reviewed.

引用

页码：54 / 59

页数：6