CALBISTRINS, NOVEL ANTIFUNGAL AGENTS PRODUCED BY PENICILLIUM-RESTRICTUM .2. ISOLATION AND ELUCIDATION OF STRUCTURE

被引：22

作者：

BRILL, GM

CHEN, RH

RASMUSSEN, RR

WHITTERN, DN

MCALPINE, JB

机构：

[1] Anti-infective Research, Abbott Laboratories, Abbott Park

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 01期

关键词：

D O I：

10.7164/antibiotics.46.39

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The novel antifungal agents, calbistrins A, B, C and D have been isolated from a strain of Penicillium restrictum (AB 1875C-28). The four congeners were separated by bioactivity directed fractionation using countercurrent chromatography and preparative-HPLC. NMR studies revealed that the calbistrins each contain a carboxylic acid conjugated tetraene attached through an aliphatic ester linkage to a hexahydronaphthalene system.

引用

页码：39 / 47

页数：9

共 6 条

[1]

FUKUYAMA K, 1976, TETRAHEDRON LETT, P189

[2]

FUKUYAMA K, 1977, J CHEM SOC P2, P683

[3] CALBISTRINS, NOVEL ANTIFUNGAL AGENTS PRODUCED BY PENICILLIUM-RESTRICTUM .1. PRODUCTION, TAXONOMY OF THE PRODUCING ORGANISM AND BIOLOGICAL-ACTIVITY [J].

JACKSON, M ;

KARWOWSKI, JP ;

HUMPHREY, PE ;

KOHL, WL ;

BARLOW, GJ ;

TANAKA, SK .

JOURNAL OF ANTIBIOTICS, 1993, 46 (01) :34-38

[4]

KAWAHARA N, 1988, CHEM PHARM BULL, V36, P398

[5] UNUSUAL FUNGAL METABOLITE, LL-N313 ZETA [J].

MCGAHREN, WJ ;

ELLESTAD, GA ;

LANCASTER, JE ;

MORTON, GO ;

KUNSTMANN, MP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1974, 96 (05) :1616-1617

[6]

SCOTT AI, 1964, INTERPRETATION ULTRA, P269

← 1 →