CALBISTRINS, NOVEL ANTIFUNGAL AGENTS PRODUCED BY PENICILLIUM-RESTRICTUM .2. ISOLATION AND ELUCIDATION OF STRUCTURE

被引：21

作者：

BRILL, GM

CHEN, RH

RASMUSSEN, RR

WHITTERN, DN

MCALPINE, JB

机构：

[1] Anti-infective Research, Abbott Laboratories, Abbott Park

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 01期

关键词：

D O I：

10.7164/antibiotics.46.39

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The novel antifungal agents, calbistrins A, B, C and D have been isolated from a strain of Penicillium restrictum (AB 1875C-28). The four congeners were separated by bioactivity directed fractionation using countercurrent chromatography and preparative-HPLC. NMR studies revealed that the calbistrins each contain a carboxylic acid conjugated tetraene attached through an aliphatic ester linkage to a hexahydronaphthalene system.

引用

页码：39 / 47

页数：9

共 6 条

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