Combining radiotherapy with hormonotherapy and targeted therapies in breast cancer

Breast cancer is one of the most important global health problems. Over the last years introduction of screening mammography and increased efficacy of adjuvant therapies resulted in the reduction of mortality in this malignancy. Many patients with breast cancer have indications for adjuvant radiotherapy and hormonotherapy, however optimal schedules of combining these two modalities remain controversial. In clinical practice typically radiotherapy and hormonotherapy are used both sequentially and concomitantly. Similarly, the most effective and safe strategies for combining radiotherapy and targeted therapies remain to be developed. It is expected that further preclinical and clinical studies, as well as rapid development of molecular oncology will contribute to better selection of patients for particular therapeutic strategies and their optimization.