Citrate during Donor Plasmapheresis

We describe the distribution of trisodium-citrate 4% anticoagulant between the product and the donors undergoing plasma donation. The paper is based upon data of 32 regular donors of plasma initially collected for a study published in 2010 [1]. These data were re-analysed to determine the amount of citrate received by the donor and the citrate infusion rate in mg/kg/min to the donor [2]. Donor plasmaphereses were performed with the automated Haemonetics r PCS2. 130 +/- 12 ml trisodium-citrate 4% was used for 760ml plasma. An average of 110 ml trisodiumcitrate 4% was in collected plasma and not given to the donor. From the difference of 20 ml trisodium- citrate 4% an average citrate infusion rate of 0.16 mg/kg/min was calculated. It was concluded that the total amount of citrate anion received by the donor is only 514 mg and that the average citrate infusion rate of 0.16mg/kg/min is very low [2].