CHARACTERIZATION OF THE BREAKPOINT OF A T(14-14)(Q11.2-Q32) FROM THE LEUKEMIC-CELLS OF A PATIENT WITH T-CELL ACUTE LYMPHOBLASTIC-LEUKEMIA

被引：27
作者：
BERTNESS, VL
FELIX, CA
MCBRIDE, OW
MORGAN, R
SMITH, SD
SANDBERG, AA
KIRSCH, IR
机构：
[1] USN HOSP,MED ONCOL BRANCH,NCI,BLDG 8,ROOM 5101,BETHESDA,MD 20814
[2] NCI,BIOCHEM LAB,BETHESDA,MD 20205
[3] SW BIOMED RES INST,SCOTTSDALE,AZ
[4] STANFORD UNIV,CHILDRENS HOSP,STANFORD,CA 94305
来源：
CANCER GENETICS AND CYTOGENETICS | 1990年 / 44卷 / 01期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/0165-4608(90)90196-H
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The leukemic cells and derivative cell line from a 74-year-old male with T-cell acute lymphoblastic leukemia showed chromosomal abnormalities including a t(14;14)(q11.2;q32). This translocation is characteristic of a variety of T-cell malignancies, particularly T-cell prolymphocytic leukemia and the clonal proliferations of peripheral T cells in patients with ataxia-telangiectasia. Using DNA probes that spanned the T-cell receptor alpha chain (TCRA) joining (J) locus, the DNA rearrangement caused by the translocation was identified, cloned, and sequenced. The breakpoint shows site-specific juxtaposition of a TCRA joining segment and DNA from a region of 14q32 centromeric to the immunoglobulin heavy chain locus. Comparison of restriction map and nucleotide sequence from this translocation with other related chromosomal breakpoints suggests a dispersion of breakpoints throughout the 14q32 region. © 1990.
引用
收藏
页码：47 / 54
页数：8
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