RELIEF OF DIASTOLIC CARDIAC DYSFUNCTION AFTER CYCLOSPORINE WITHDRAWAL IN A CARDIAC TRANSPLANT RECIPIENT

被引：9

作者：

SIOSTRZONEK, P

TEUFELSBAUER, H

KREINER, G

LACZKOVICS, A

GOSSINGER, H

HEINZ, G

STUMPFLEN, A

MOSSLACHER, H

机构：

[1] UNIV VIENNA,DEPT MED 1,A-1090 VIENNA,AUSTRIA

[2] UNIV VIENNA,DEPT SURG 2,A-1090 VIENNA,AUSTRIA

来源：

EUROPEAN HEART JOURNAL | 1993年 / 14卷 / 06期

关键词：

CARDIAC TRANSPLANTATION; CYCLOSPORINE; HEART FAILURE;

D O I：

10.1093/eurheartj/14.6.859

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Severe heart failure developed in a 49-year-old patient 18 months after orthotopic cardiac transplantation. Acute rejection as well as other overt causes of graft failure were excluded. Haemodynamic measurements suggested severe diastolic myocardial dysfunction. Since no other causes of diastolic heart failure were identified, a potential side effect from cyclosporine was considered. Cyclosporine was therefore withdrawn and immunosuppressive treatment was switched to conventional therapy consisting of azathioprine and prednisolone. Withdrawal of cyclosporine was followed by an impressive clinical improvement and by complete haemodynamic normalization. Therefore, in cases of otherwise unexplained graft failure, a potentially reversible side effect from cyclosporine should be taken into consideration. © 1993 The European Society of Cardiology.

引用

收藏

页码：859 / 861

页数：3

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