1-ALKYL-3-(1-NAPHTHOYL)PYRROLES - A NEW CLASS OF CANNABINOID

被引：113

作者：

LAINTON, JAH

HUFFMAN, JW

MARTIN, BR

COMPTON, DR

机构：

[1] CLEMSON UNIV,DEPT CHEM,CLEMSON,SC 29634

[2] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOL,RICHMOND,VA 23298

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 09期

关键词：

D O I：

10.1016/0040-4039(95)00016-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The design and synthesis of a series of 1-alkyl-3-(1-naphthoyl)pyrroles is described Molecular modeling studies were employed to aid in the design of these compounds. During the course of the synthesis the Friedel-Crafts reactions of N-aryl sulfonyl pyrroles were reinvestigated. The title compounds (4) were subjected to pharmacological evaluation and the data obtained have enabled these pyrroles to be classified as cannabinoids.

引用

页码：1401 / 1404

页数：4

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