1-ALKYL-3-(1-NAPHTHOYL)PYRROLES - A NEW CLASS OF CANNABINOID

被引：113
作者：
LAINTON, JAH
HUFFMAN, JW
MARTIN, BR
COMPTON, DR
机构：
[1] CLEMSON UNIV,DEPT CHEM,CLEMSON,SC 29634
[2] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOL,RICHMOND,VA 23298
来源：
TETRAHEDRON LETTERS | 1995年 / 36卷 / 09期
关键词：
D O I：
10.1016/0040-4039(95)00016-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The design and synthesis of a series of 1-alkyl-3-(1-naphthoyl)pyrroles is described Molecular modeling studies were employed to aid in the design of these compounds. During the course of the synthesis the Friedel-Crafts reactions of N-aryl sulfonyl pyrroles were reinvestigated. The title compounds (4) were subjected to pharmacological evaluation and the data obtained have enabled these pyrroles to be classified as cannabinoids.
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页码：1401 / 1404
页数：4
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