EVIDENCE FOR A DOPAMINE-RECEPTOR SUBTYPE SENSITIVE TO COMBINATION OF D1 WITH D2 ANTAGONIST IN MEASUREMENT OF G-PROTEIN ACTIVITY USING RAT STRIATAL MEMBRANES

被引：3
|
作者：
YUE, JL
UEDA, H
MISU, Y
机构：
[1] Department of Pharmacology, Yokohama City University School of Medicine, Kanazawa-Ku, Yokohama, 236
来源：
LIFE SCIENCES | 1994年 / 54卷 / 23期
关键词：
DOPAMINE RECEPTOR AGONIST; G-PROTEIN; GTPASE ACTIVITY; STRIATAL MEMBRANES;
D O I：
10.1016/0024-3205(94)90125-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In rat striatal membranes, various kinds of dopamine receptor agonists stimulated low-Km GTPase activity in a concentration-dependent manner. This stimulation by bromocriptine, pergolide and apomorphine was partially inhibited by sulpiride (SUL), a D2-selective antagonist, markedly inhibited by combination of SUL with SCH 23390 (SCH), a D1-selective antagonist, and not modified by SCH alone. The stimulation by BAM-1110 was resistant to SUL or SCH alone but abolished by combination of SUL with SCH. These findings suggest the presence of another subtype of a dopamine receptor in a functional in vitro bioassay system in rat striata.
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页码：PL413 / PL418
页数：6
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