EPIDERMAL GROWTH-FACTOR - INDUCED IMPLANTATION AND DECIDUALIZATION IN THE RAT

被引：24
|
作者：
TAMADA, H
KAI, Y
MORI, J
机构：
[1] Department of Animal Reproduction, College of Agriculture, University of Osaka Prefecture, Sakai, Osaka
来源：
PROSTAGLANDINS | 1994年 / 47卷 / 06期
关键词：
EGF; IMPLANTATION; DECIDUALIZATION; INDOMETHACIN; RAT;
D O I：
10.1016/0090-6980(94)90046-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Effects of epidermal growth factor (EGF) on blastocyst implantation and experimentally-induced decidualization were examined in the rat. Intraluminal injection of EGF into each uterine horn induced implantation in the ovariectomized progesterone-treated delayed implanting rat in a dose-dependent manner. This induction was inhibited by indomethacin, an inhibitor of prostaglandin synthesis. Intraluminal injection of EGF on day 5 of pseudopregnancy elicited a greater decidual response when compared to the vehicle-injected contralateral uterine horn. These results suggest that EGF may play important roles in the process of implantation and decidualization in the rat.
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页码：467 / 475
页数：9
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