ALTERATIONS OF BRAIN-METABOLITES IN METACHROMATIC LEUKODYSTROPHY AS DETECTED BY LOCALIZED PROTON MAGNETIC-RESONANCE SPECTROSCOPY IN-VIVO

被引：93

作者：

KRUSE, B ^{[1
]}

HANEFELD, F ^{[1
]}

CHRISTEN, HJ ^{[1
]}

BRUHN, H ^{[1
]}

MICHAELIS, T ^{[1
]}

HANICKE, W ^{[1
]}

FRAHM, J ^{[1
]}

机构：

[1] MAX PLANCK INST BIOPHYS CHEM,D-37085 GOTTINGEN,GERMANY

来源：

JOURNAL OF NEUROLOGY | 1993年 / 241卷 / 02期

关键词：

METACHROMATIC LEUKODYSTROPHY; MYOINOSITOL BRAIN METABOLISM; MAGNETIC RESONANCE IMAGING; PROTON MAGNETIC RESONANCE SPECTROSCOPY;

D O I：

10.1007/BF00869766

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The brain morphology and chemistry of seven children with late infantile (4/7) and juvenile (3/7) forms of metachromatic leukodystrophy (MLD) were investigated by magnetic resonance imaging (MRI) and localized proton magnetic resonance spectroscopy (MRS). Patients who were examined at least 6 months after the onset of symptoms (6/7) had severe leukodystrophic changes on MRI. Proton MRS revealed a marked reduction of the neuronal marker N-acetylaspartate in white and grey matter and elevated lactate in demyelinated areas. In contrast to other leukodystrophies MLD patients showed a generalized increase of brain myo-inositol (2- to 3-fold in white matter), indicating a specific role in the pathophysiology of demyelination in MLD.

引用

页码：68 / 74

页数：7

共 28 条

[1]

BRAND A, 1992, 11TH SOC MAGN RES ME, P649

[2] MULTIPLE-SCLEROSIS IN CHILDREN - CEREBRAL METABOLIC ALTERATIONS MONITORED BY LOCALIZED PROTON MAGNETIC-RESONANCE SPECTROSCOPY INVIVO [J].