A QSAR INVESTIGATION OF DIHYDROFOLATE-REDUCTASE INHIBITION BY BAKER TRIAZINES BASED UPON MOLECULAR SHAPE-ANALYSIS

被引：221

作者：

HOPFINGER, AJ

机构：

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1980年 / 102卷 / 24期

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D O I：

10.1021/ja00544a005

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

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页码：7196 / 7206

页数：11

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共 27 条

[1] CALCULATION OF STRUCTURES OF HYDROCARBONS CONTAINING DELOCALIZED ELECTRONIC SYSTEMS BY MOLECULAR MECHANICS METHOD [J].

ALLINGER, NL ;

SPRAGUE, JT .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (12) :3893-3907

[2]

[Anonymous], CONFORMATIONAL PROPE

[3] THEORETICAL TREATMENT OF MULTIPLE SITE REACTIVITY IN LARGE MOLECULES [J].

BARTLETT, RJ ;

WEINSTEIN, H .

CHEMICAL PHYSICS LETTERS, 1975, 30 (03) :441-447

[4] STEREOCHEMISTRY OF DIHYDROFOLATE-REDUCTASE INHIBITOR ANTI-TUMOR AGENTS - MOLECULAR-STRUCTURE OF BAKER ANTIFOL (NSC-139105, TRIAZINATE) AND INSOLUBLE BAKER ANTIFOL (NSC-113423) [J].

CAMERMAN, A ;

SMITH, HW ;

CAMERMAN, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1978, 83 (01) :87-93

[5] BC(DEF) PARAMETERS .2. EMPIRICAL STRUCTURE-BASED SCHEME FOR THE PREDICTION OF SOME PHYSICAL-PROPERTIES [J].

CRAMER, RD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (06) :1849-1859

[6] BC(DEF) PARAMETERS .1. INTRINSIC DIMENSIONALITY OF INTERMOLECULAR INTERACTIONS IN THE LIQUID-STATE [J].

CRAMER, RD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (06) :1837-1849

[7] DISTANCE GEOMETRY APPROACH TO RATIONALIZING BINDING DATA [J].

CRIPPEN, GM .

JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (08) :988-997

[8] DIHYDROFOLATE-REDUCTASE INHIBITION BY 2,4-DIAMINOTRIAZINES - STRUCTURE-ACTIVITY STUDY [J].

DIETRICH, SW ;

SMITH, RN ;

FUKUNAGA, JY ;

OLNEY, M ;

HANSCH, C .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1979, 194 (02) :600-611

[9] USE OF TRIAZINE INHIBITORS IN MAPPING THE ACTIVE-SITE REGION OF LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE [J].

DIETRICH, SW ;

SMITH, RN ;

BRENDLER, S ;

HANSCH, C .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1979, 194 (02) :612-619

[10]

HAM NS, 1974, MOL QUANTUM PHARM, P261