A SYSTEM FOR THE RISK ASSESSMENT OF STEVENS-JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROLYSIS APPEARANCE

被引：0
作者：
Zimenkovsky, A. [1 ]
Gorodnycha, O. [1 ]
机构：
[1] Danylo Halytsky Lviv Natl Med Univ, Dept Clin Pharm Pharmacotherapy & Med Standardiza, 69 Pekarska Str, UA-79010 Lvov, Ukraine
来源：
PHARMACIA | 2013年 / 60卷 / 04期
关键词：
Stevens-Johnson syndrome; toxic epidermal necrolysis; risk assessment;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions (ADR). In this study established that the risk of SJS/TEN appearance is increased according to the number of potential cutaneous ADR that are the symptoms of these syndromes (chi(2)=23.95; odds ratio 1.56 [confidence interval 95%, 1.29-1.88]; p<0,001). All drugs associated with the risk of SJS/TEN appearance were combined into 7 groups by the << GDD >> - grade of dermatological danger. Thus, the risk of SJS/TEN appearance is considerably lower if drug with GDD << 1 >> has been administrated compared to drug with GDD << 7 >>
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页码：31 / 36
页数：6
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