ALFENTANIL INFUSION IN TOTAL INTRAVENOUS ANESTHESIA (TIVA) - POPULATION PHARMACOKINETICS FAILS TO PREDICT PLASMA-CONCENTRATION OF ALFENTANIL

被引：4

作者：

JENSTRUP, M ^{[1
]}

FRUERGARD, K ^{[1
]}

NIELSEN, J ^{[1
]}

MOLLER, AM ^{[1
]}

WIBERGJORGENSEN, F ^{[1
]}

机构：

[1] CENT HOSP HILLEROD,DEPT ANAESTHESIOL,HILLEROD,DENMARK

来源：

ACTA ANAESTHESIOLOGICA SCANDINAVICA | 1992年 / 36卷 / 08期

关键词：

ANALGESICS; ALFENTANIL; HYPNOTICS; PROPOFOL; PHARMACOKINETICS; TOTAL INTRAVENOUS ANESTHESIA;

D O I：

10.1111/j.1399-6576.1992.tb03576.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

In order to evaluate the ability to predict plasma concentrations from population-corrected pharmacokinetics, a prospective study comprising 14 women admitted for elective hysterectomy was done. Alfentanil was given in combination with propofol in a total intravenous anaesthesia technique. The predicted median alfentanil concentration (289(256-363) ng ml-1) was significantly lower than the measured median plasma concentration of 368(168-666) ng ml-1). In conclusion, population-based pharmacokinetics were found not to be accurate as they underestimate plasma concentrations of alfentanil.

引用

页码：846 / 847

页数：2

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