NUCLEAR-MEDICINE PATIENTS DO NOT HAVE HIGHER MUTANT FREQUENCIES AFTER EXPOSURE TO TL-201

被引：15
作者：
BACHAND, M [1 ]
SEIFERT, AM [1 ]
MESSING, K [1 ]
机构：
[1] UNIV QUEBEC,DEPT SCI BIOL,CP 8888,SUCC A,MONTREAL H3C 3P8,QUEBEC,CANADA
来源：
MUTATION RESEARCH | 1991年 / 262卷 / 01期
基金：
加拿大自然科学与工程研究理事会;
关键词：
TL-201; EXPOSURE; MUTANT FREQUENCY;
D O I：
10.1016/0165-7992(91)90097-N
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The HPRT-lymphocyte clonal assay has been used to detect mutants induced in vivo in humans. This method has previously detected a rise in mutant frequency among nuclear medicine patients following exposure to technetium-99m, at a dose corresponding in theory to 5.1 mGy. In the present study, nuclear medicine patients were sampled before and after exposure to thallium-201, corresponding to a whole-body dose of 4.2 mGy. No rise in mutant frequency was found. We suggest that a difference in the effective dose received by the patients' lymphocytes accounts for the apparent contradiction with earlier results.
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页码：1 / 6
页数：6
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