LOCALIZATION OF THE GROWTH-HORMONE GENE TO THE DISTAL HALF OF MOUSE CHROMOSOME-11

被引：10

作者：

ELLIOTT, RW ^{[1
]}

LEE, BK ^{[1
]}

EICHER, EM ^{[1
]}

机构：

[1] JACKSON LAB,BAR HARBOR,ME 04609

来源：

GENOMICS | 1990年 / 8卷 / 03期

关键词：

D O I：

10.1016/0888-7543(90)90051-U

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A DNA fragment size variant for the growth hormone gene, Gh, has been identified among inbred strains of mice. The inbred strains SM J and CAST Ei carry the less frequent allele Ghb and 11 other strains carry the Ghα allele. Segregation analysis of data from two crosses involving SM J and NZB BINJ and a cross involving BALB cJ and CAST Ei confirmed the assignment of Gh to mouse chromosome 11 and placed the locus 2.6 ± 1.8 map units distal to Erba (avian erythroblastosis oncogene A), a position consistent with the assignment of the Gh locus to the q22-q24 region of chromosome 17 on the human map. Segregation analysis also refined the location of Sparc (secreted acidic cysteine-rich glycoprotein) on mouse chromosome 11 to a position 16.7 ± 4.2 map units proximal to Evi-2 (ecotropic viral integration site 2). © 1990.

引用

页码：591 / 594

页数：4

共 21 条

[1] CLOSE GENETIC AND PHYSICAL LINKAGE BETWEEN THE MURINE HEMATOPOIETIC GROWTH-FACTOR GENES GM-CSF AND MULTI-CSF (IL3) [J].