ANTIMICROBIAL ACTIVITY OF DIMETHYL SULFOXIDE AGAINST ESCHERICHIA COLI, PSEUDOMONAS AERUGINOSA, AND BACILLUS MEGATERIUM

被引：63

作者：

ANSEL, HC

NORRED, WP

ROTH, IL

机构：

[1] School of Pharmacy, University of Georgia, Athens, Georgia

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 07期

关键词：

Antimicrobial activity–DMSO solutions; Dimethyl sulfoxide–antimicrobial activity; Electron microscopy–cells exposed to DMSO; Turbidimetric analysis–bacterial suspensions;

D O I：

10.1002/jps.2600580708

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A study has been made of the antimicrobial activity of dimethyl sulfoxide (DMSO) against three organisms, Escherichia coli, Pseudomonas aeruginosa, and Bacillus megaterium. Growth was inhibited by increasing DMSO levels and was virtually eliminated for each of the species at approximately 15% DMSO. P. aeruginosa demonstrated the least resistance to DMSO inhibition, with over 90% inhibition occurring in the presence of 8% DMSO. The growth rates of each of the microorganisms were shown to be decreased with increasing concentrations of DMSO. Electron microscopy revealed increased cytological alterations with increased concentrations of DMSO. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：836 / &

共 27 条

[1] HEMOLYSIS OF ERYTHROCYTES BY ANTIBACTERIAL PRESERVATIVES [J].