Effects of Dopamine Reuptake Inhibitors on Food- and Cocaine-Maintained Responding: II. Comparisons With Other Drugs and Repeated Administrations

被引：66

作者：

Glowa, John R. ^{[1
]}

Wojnicki, Francis H. E. ^{[1
]}

Matecka, Dorota ^{[1
]}

Rice, Kenner C. ^{[1
]}

Rothman, Richard B. ^{[2
]}

机构：

[1] NIDDK, Lab Med Chem, NIH, Bethesda, MD USA

[2] NIDA, Clin Psychopharmacol Sect, Addict Res Ctr, Baltimore, MD USA

来源：

EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY | 1995年 / 3卷 / 03期

关键词：

D O I：

10.1037/1064-1297.3.3.232

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

A previous study (J.R. Glowa, F.H.E. Wojnicki, D. Matecka, et al, 1995) showed that acute doses of GBR 12909 selectively decreased cocaine-maintained responding without affecting food-maintained responding. This report extended these observations to some related drugs and to the effects of repeated administration. When responding was maintained under a multiple fixed ratio (FR) 30 food, FR 30 cocaine schedule, acute doses of GBR 12935, CFT, and d-amphetamine decreased cocaine-maintained responding more than food-maintained responding. However, in contrast to GBR 12909, none of these drugs completely decreased cocaine-maintained responding without affecting food-maintained responding. Repeated administration of GBR 12909 sustained, and of GBR 12935 improved, these selective decreases in cocaine-maintained responding. The selective effect of these dopamine reuptake inhibitors on cocaine-maintained responding is consistent with their known pharmacological selectivity for the dopamine reuptake site and can be well-maintained with repeated administration.

引用

页码：232 / 239

页数：8

共 15 条

[1] THE DOPAMINE UPTAKE INHIBITOR GBR 12909 - SELECTIVITY AND MOLECULAR MECHANISM OF ACTION [J].