NOVEL HIV-1 PROTEASE INHIBITORS CONTAINING A BETA-HYDROXY SULFIDE ISOSTERE

被引：6

作者：

CHO, SYS ^{[1
]}

JUNGHEIM, LN ^{[1
]}

BAXTER, AJ ^{[1
]}

机构：

[1] ELI LILLY & CO,LILLY RES LAB,INDIANAPOLIS,IN 46285

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(01)80186-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of analogues of LY289612 were prepared as HIV-1 protease inhibitors and evaluated in vitro for their enzyme inhibitory and antiviral activities. Compound 1, a potent HIV-1 protease inhibitor, and its analogues were synthesized from key intermediate 9, which was prepared by alkylation of mercaptan 4 with alpha-bromo ketone 7 followed by stereoselective reduction of the ketone intermediate 8.

引用

页码：715 / 720

页数：6

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