SIMPLE PREPARATIONS OF TRICYCLIC ORTHOAMIDES AND MACROCYCLIC TRIAMINES

被引：17

作者：

KIM, RD ^{[1
]}

WILSON, M ^{[1
]}

HASELTINE, J ^{[1
]}

机构：

[1] GEORGIA INST TECHNOL,SCH CHEM & BIOCHEM,ATLANTA,GA 30332

来源：

SYNTHETIC COMMUNICATIONS | 1994年 / 24卷 / 21期

关键词：

D O I：

10.1080/00397919408011324

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hexahydropyrimidopyrimidine 3 is condensed with an alkyl ditosylate 4 at room temperature in DME or toluene. The resulting tricyclic salt is reduced with sodium borohydride to provide orthoamides 6a-c. Acidic hydrolysis of these orthoamides gives the corresponding macrocyclic triamines 8a-c in high yield.

引用

页码：3109 / 3114

页数：6

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