SYNTHESIS AND ANTIFUNGAL ACTIVITY OF NOVEL CATIONIC PNEUMOCANDIN B-O DERIVATIVES

被引：95
作者：
BOUFFARD, FA
ZAMBIAS, RA
DROPINSKI, JF
BALKOVEC, JM
HAMMOND, ML
ABRUZZO, GK
BARTIZAL, KF
MARRINAN, JA
KURTZ, MB
MCFADDEN, DC
NOLLSTADT, KH
POWLES, MA
SCHMATZ, DM
机构：
[1] MERCK RES LABS,DEPT SYNTHET CHEM RES,RAHWAY,NJ 07065
[2] MERCK SHARP & DOHME LTD,RES LABS,DEPT ANTIBIOT DISCOVERY & DEV,RAHWAY,NJ 07065
[3] MERCK SHARP & DOHME LTD,RES LABS,DEPT INFECT DIS RES,RAHWAY,NJ 07065
[4] MERCK SHARP & DOHME LTD,RES LABS,DEPT PARASITE BIOCHEM & CELL BIOL,RAHWAY,NJ 07065
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 37卷 / 02期
关键词：
D O I：
10.1021/jm00028a003
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：222 / 225
页数：4
相关论文
共 50 条
[1]  
ARTYMOWICZ RJ, 1993, CLIN PHARMACY, V12, P563
[2]   REDUCTION STUDIES OF ANTIFUNGAL ECHINOCANDIN LIPOPEPTIDES - ONE-STEP CONVERSION OF ECHINOCANDIN-B TO ECHINOCANDIN-C [J].
BALKOVEC, JM ;
BLACK, RM .
TETRAHEDRON LETTERS, 1992, 33 (32) :4529-4532
[3]   SYNTHESIS, STABILITY, AND BIOLOGICAL EVALUATION OF WATER-SOLUBLE PRODRUGS OF A NEW ECHINOCANDIN LIPOPEPTIDE - DISCOVERY OF A POTENTIAL CLINICAL AGENT FOR THE TREATMENT OF SYSTEMIC CANDIDIASIS AND PNEUMOCYSTIS-CARINII PNEUMONIA (PCP) [J].
BALKOVEC, JM ;
BLACK, RM ;
HAMMOND, ML ;
HECK, JV ;
ZAMBIAS, RA ;
ABRUZZO, G ;
BARTIZAL, K ;
KROPP, H ;
TRAINOR, C ;
SCHWARTZ, RE ;
MCFADDEN, DC ;
NOLLSTADT, KH ;
PITTARELLI, LA ;
POWLES, MA ;
SCHMATZ, DM .
JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (01) :194-198
[4]   INVITRO ANTIFUNGAL ACTIVITIES AND INVIVO EFFICACIES OF 1,3-BETA-D-GLUCAN SYNTHESIS INHIBITORS L-671,329, L-646,991, TETRAHYDROECHINOCANDIN-B, AND L-687,781, A PAPULACANDIN [J].
BARTIZAL, K ;
ABRUZZO, G ;
TRAINOR, C ;
KRUPA, D ;
NOLLSTADT, K ;
SCHMATZ, D ;
SCHWARTZ, R ;
HAMMOND, M ;
BALKOVEC, J ;
VANMIDDLESWORTH, F .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (08) :1648-1657
[5]  
BARTIZAL K, 1993, CUTANEOUS ANTIFUNGAL, P421
[6]  
BEAULIEU D, 1993, FEMS MICROBIOL LETT, V108, P133
[7]   METABOLIC PRODUCTS OF MICROORGANISM .143. ECHINOCANDIN B, A NEW POLYPEPTIDE ANTIBIOTIC FROM ASPERGILLUS NIDULANS VAR ECHINULATUS - ISOLATION AND BUILDING UNITS [J].
BENZ, F ;
KNUSEL, F ;
NUESCH, J ;
TREICHLER, HJ ;
VOSER, W .
HELVETICA CHIMICA ACTA, 1974, 57 (08) :2459-2477
[8]  
BRAJTBURG J, 1992, RECENT PROGRESS IN ANTIFUNGAL CHEMOTHERAPY, P65
[9]   AMPHOTERICIN-B - DELIVERY SYSTEMS [J].
BRAJTBURG, J ;
POWDERLY, WG ;
KOBAYASHI, GS ;
MEDOFF, G .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (03) :381-384
[10]  
CLARK AM, 1992, NEW APPROACHES ANTIF, P2
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