A COMMON DELETION IN 2 GAMMA-RAY INDUCED RAT PULMONARY TUMOR-CELL LINES

被引：0
作者：
VANKLAVEREN, P
DEBRUIJNE, J
VANDERWINDEN, H
KAL, HB
BENTVELZEN, P
机构：
来源：
ANTICANCER RESEARCH | 1994年 / 14卷 / 2A期
关键词：
RADIATION CARCINOGENESIS; DELETION; GENOMIC SUBTRACTION;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Subtraction hybridization was performed on normal WAG/Rij rat DNA with DNA from a syngeneic Ir-192 induced pulmonary tumor cell line L37. The residual DNA was amplified by means of sequence-independent PCR. This procedure yielded a sequence, of which multiple copies are present in normal rat DNA. In the tumor line L37 two restriction. fragments hybridizing with this repeat sequence are lacking. In another Ir-192 induced pulmorary tumor line, L33, one of these fragments was also lacking. This indicates a common deletion in the two tumor lines.
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页码：565 / 569
页数：5
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