SIMULTANEOUS DETERMINATION OF IN-VIVO HYDROXYLATION OF TYROSINE AND TRYPTOPHAN IN RAT STRIATUM BY MICRODIALYSIS-HPLC - RELATIONSHIP BETWEEN DOPAMINE AND SEROTONIN BIOSYNTHESIS

被引:41
作者
HASHIGUTI, H
NAKAHARA, D
MARUYAMA, W
NAOI, M
IKEDA, T
机构
[1] NAGOYA UNIV,COLL MED TECHNOL,DEPT PSYCHOL,1-20 DAIKOMINAMI 1 CHOME,HIGASHI KU,NAGOYA 461,JAPAN
[2] NAGOYA UNIV,SCH MED,DEPT NEUROL,NAGOYA,AICHI 466,JAPAN
[3] MIYAZAKI MED COLL,DEPT PSYCHIAT,MIYAZAKI 88916,JAPAN
[4] NAGOYA INST TECHNOL,DEPT BIOSCI,NAGOYA,AICHI 466,JAPAN
关键词
TYROSINE HYDROXYLASE; TRYPTOPHAN HYDROXYLASE; MONOAMINE METABOLISM; L-DOPA; L-5-HYDROXYTRYPTOPHAN; MICRODIALYSIS;
D O I
10.1007/BF01244998
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Using a microdialysis technique,the rat striatum was perfused with NSD-1015, an inhibitor of aromatic L-amino acid decarboxylase, and the amount of L-3,4-dihydroxyphenylalanine (L-DOPA) and 5-hydroxytrytophan (5-HTP) accumulating in dialysate was measured as an index of in vivo activities of tyrosine hydroxylase and tryptophan hydroxylase. NSD-1015 increased the concentration of L-DOPA much higher than that of 5-HTP in a dose-related manner (1-100 mumol/L). In order to examine the relationship between dopaminergic and serotonergic neurons in the striatum, either 5-HTP or L-DOPA was injected intraperitoneally to rats pretreated with benserazide, an inhibitor of peripheral decarboxylase. 5-HTP administration increased 5-HTP, but decreased L-DOPA in a dose-dependent manner. Conversely, 5-HTP concentration decreased in an association with the increased content of L-DOPA following L-DOPA administration. The decrease of 5-HTP caused by L-DOPA administration was not as remarkable as that of L-DOPA by 5-HTP injection. These results suggest that L-DOPA and 5-HTP, the precursor amino acids for catecholamines and indoleamines, could affect mutually each other neuronal activity through the inhibition of their rate-limiting enzymes.
引用
收藏
页码:213 / 223
页数:11
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