THE EFFECTS OF CISPLATIN ON THE EPIPHYSEAL GROWTH-PLATE

被引：0
作者：
MIYOSHI, K [1 ]
IWAMOTO, Y [1 ]
SUGIOKA, Y [1 ]
机构：
[1] KYUSHU UNIV,FAC MED,DEPT ORTHOPED SURG,HIGASHI KU,FUKUOKA 812,JAPAN
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 1994年 / 4卷 / 05期
关键词：
CISPLATIN; EPIPHYSEAL GROWTH PLATE; ALKALINE PHOSPHATASE; CARTILAGE BIOSYNTHESIS;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In rabbit models, the inhibition of proteoglycan (PG) biosynthesis in the epiphyseal growth plate of the ribs was observed in the group given cisplatin both in vitro and in vitro. Serum alkaline phosphatase (ALP) and the bone-derived ALP isoenzyme were observed to decrease in the young rabbits given cisplatin. In rat models, the length of the tibias in both the groups given cisplatin was significantly shorter than that of those in the control rats. The results described may thus suggest that the injury of the epiphyseal growth plate and growth retardation possibly occur due to the use of cisplatin.
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页码：1105 / 1109
页数：5
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