DOPA-RESPONSIVE DYSTONIA WITH DEPIGMENTATION OF THE SUBSTANTIA-NIGRA AND FORMATION OF LEWY BODIES

被引：13

作者：

OLSSON, JE

BRUNK, U

LINDVALL, B

EEGOLOFSSON, O

机构：

[1] LINKOPING UNIV,FAC HLTH SCI,DEPT NEUROL,S-58185 LINKOPING,SWEDEN

[2] LINKOPING UNIV,FAC HLTH SCI,DEPT PATHOL,S-58185 LINKOPING,SWEDEN

[3] LINKOPING UNIV,FAC HLTH SCI,DEPT PEDIAT,S-58185 LINKOPING,SWEDEN

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1992年 / 112卷 / 1-2期

关键词：

DYSTONIA; JUVENILE PARKINSONISM; DOPA RESPONSIVENESS; MONOAMINE DEFICIENCY; LEWY BODIES;

D O I：

10.1016/0022-510X(92)90137-A

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The patient, who died at 23 years of age, was first diagnosed when she was 12 year old as having a dopa-responsive dystonia with decreased concentrations of monoamine metabolites in the cerebrospinal fluid. Also the concentrations of other neurotransmitters including somatostatin, substance P and metenkefalin were lowered indicating a more widespread damage of the cerebral neurotransmittor systems. At autopsy the brain was essentially intact except for pronounced gliosis and extreme loss of melanotic nerve cells in the substantia nigra. Several remaining nerve cells showed the presence of Lewy bodies.

引用

页码：90 / 95

页数：6