THE DENSITY OF RYANODINE RECEPTORS DECREASES WITH PRESSURE OVERLOAD-INDUCED RAT CARDIAC-HYPERTROPHY

被引：62

作者：

NAUDIN, V ^{[1
]}

OLIVIERO, P ^{[1
]}

RANNOU, F ^{[1
]}

SAINTEBEUVE, C ^{[1
]}

CHARLEMAGNE, D ^{[1
]}

机构：

[1] HOP LARIBOISIERE,INSERM,U127,41 BD DE LA CHAPELLE,F-75475 PARIS 10,FRANCE

来源：

FEBS LETTERS | 1991年 / 285卷 / 01期

关键词：

RAYNODINE RECEPTORS; HYPERTROPHIED RAT HEART;

D O I：

10.1016/0014-5793(91)80743-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigate the possibility that alterations in the calcium movements of the hypertrophied rat heart might involve sarcoplasmic reticulum (SR) ryanodine receptors. A decreased receptor density was observed with severe hypertrophy (0.26 +/- 0.05 and 0.35 +/- 0.06 pmol/mg protein and 170 and 366 receptors/mu-m2 of SR in 50-80% hypertrophy and control, respectively); however, the total number of receptors per left ventricle was unchanged. The dissociation constant (0.7 nM) was similar in both hypertrophied and control left ventricles. Thus the decreased density of the ryanodine receptors may participate in altered calcium movements in hypertrophied rat heart.

引用

页码：135 / 138

页数：4

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