CHOLINE EXCITES CORTICAL-NEURONS

被引：73

作者：

KRNJEVIC, K ^{[1
]}

REINHARDT, W ^{[1
]}

机构：

[1] MCGILL UNIV,DEPT PHYSIOL,MONTREAL H3G 1Y6,QUEBEC,CANADA

来源：

SCIENCE | 1979年 / 206卷 / 4424期

关键词：

D O I：

10.1126/science.515735

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In cats under halothane or methoxyflurane, iontophoretic applications of choline are only eight times weaker than applications of acetylcholine in evoking firing of neurons in the sensorimotor region of the cerebral cortex. The action of choline is suppressed by atropine but not by two agents that block choline uptake (hemicholinium-3 and triethylcholine), and is not potentiated by an anticholinesterase (physostigmine). Choline therefore appears to excite cortical neurons by a direct action, which may be a significant component of its beneficial therapeutic effects. Copyright © 1979 AAAS.

引用

页码：1321 / 1323

页数：3

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