ANTIMALARIAL DRUG RESPONSE OF PLASMODIUM-FALCIPARUM FROM ZARIA, NIGERIA

被引：27

作者：

ADAGU, IS

WARHURST, DC

OGALA, WN

ABDUAGUYE, I

AUDU, LI

BAMGBOLA, FO

OVWIGHO, UB

机构：

[1] AHMADU BELLO UNIV HOSP,DEPT PAEDIAT,ZARIA,NIGERIA

[2] AHMADU BELLO UNIV,DEPT PHARMACOL & CLIN PHARM,ZARIA,NIGERIA

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1995年 / 89卷 / 04期

关键词：

MALARIA; PLASMODIUM FALCIPARUM; DRUG SENSITIVITY; NIGERIA;

D O I：

10.1016/0035-9203(95)90037-3

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The sensitivity of Zaria strains of Plasmodium falciparum to chloroquine, mefloquine, quinine and sulphadoxine/pyrimethamine was investigated 5 years after the appearance of in vivo/in vitro chloroquine resistance in urban Zaria. Infections in 36/43 children (83.7%) treated with chloroquine were sensitive while those in 7(16.3%) were resistant. 8/13 isolates cultured (61.5%) were sensitive in vitro to chloroquine and 5(38.5%) were resistant. Of the cultured isolates, 13/13(100%), 12/13(92.3%) and 5/7(71.4%) showed mefloquine, quinine and sulphadoxine/pylimethamine sensitivity, respectively. The results confirmed chloroquine and sulphadoxine/pyrimethamine resistance in urban Zaria and revealed emerging quinine resistance. Resistance to chloroquine and sulphadoxine/pyrimethamine is at RI level and chloroquine should continue to be the first-line drug for the treatment and prevention of P. falciparum infection in the Zaria area of northern Nigeria. We suggest that, while quinine serves as second-line drug mefloquine should be reserved for infections resistant to chloroquine, quinine and sulphadoxine/pyrimethamine.

引用

页码：422 / 425

页数：4