COMPARISON OF THE EFFECTS OF SEVOFLURANE AND HALOTHANE ON THE QUALITY OF ANESTHESIA AND SERUM GLUTATHIONE TRANSFERASE-ALPHA AND FLUORIDE IN PEDIATRIC-PATIENTS

被引：48

作者：

TAIVAINEN, T ^{[1
]}

TIAINEN, P ^{[1
]}

MERETOJA, OA ^{[1
]}

RAIHA, L ^{[1
]}

ROSENBERG, PH ^{[1
]}

机构：

[1] UNIV HELSINKI, CENT HOSP, SURG HOSP, DEPT ANAESTHESIOL, SF-00290 HELSINKI, FINLAND

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1994年 / 73卷 / 05期

关键词：

ANESTHESIA; PEDIATRIC; ANESTHETICS VOLATILE; HALOTHANE; SEVOFLURANE;

D O I：

10.1093/bja/73.5.590

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

We have compared sevoflurane and halothane anaesthesia in paediatric patients with reference to induction and recovery. We also assessed hepatocellular integrity by measurement of serum glutathione transferase alpha (GSTA) concentration and sevoflurane metabolism by serum fluoride concentration. Fifty unpremedicated 5-12-yr-old children were allocated randomly to induction of anaesthesia via a face mask with 66% nitrous oxide in oxygen and sevoflurane (up to 7%) or halothane (up to 3.5%). Anaesthesia was maintained for 1.8 h at 1-1.2 MAC of the volatile agent. Children receiving sevoflurane had significantly faster induction and recovery variables than those receiving halothane. There was a small postanaesthetic increase in GSTA in both groups, suggesting that halothane and sevoflurane may disturb hepatocellular integrity. Serum concentrations of fluoride were significantly greater after sevoflurane than after halothane anaesthesia. There were no clinical signs or symptoms of hepatic or renal disturbance. Children tolerated sevoflurane better than halothane, which may have been because of the nonpungency of sevoflurane and the rapid psychomotor recovery after anaesthesia.

引用

页码：590 / 595

页数：6

共 31 条

[1]

DAVIS PJ, 1993, ANESTHESIOLOGY, V79, pA1165

[2]

DOI M, 1993, CAN J ANAESTH, V40, P122, DOI 10.1007/BF03011308

[3]

DOI M, 1987, ANESTH ANALG, V66, P241

[4]

DOJOVNE CA, 1967, NEW ENGL J MED, V277, P785

[5]

DUBOIS MC, 1994, BRIT J ANAESTH, V72, P97

[6]

EGER EI, 1987, ANESTH ANALG, V66, P971

[7]

EGER EI, 1992, ANESTH ANALG, V75, pS3

[8] CLINICAL COMPARISON OF SEVOFLURANE AND ISOFLURANE IN HEALTHY PATIENTS [J].

FRINK, EJ ;

MALAN, TP ;

ATLAS, M ;

DOMINGUEZ, LM ;

DINARDO, JA ;

BROWN, BR .

ANESTHESIA AND ANALGESIA, 1992, 74 (02) :241-245

[9]

FRY BW, 1970, J LAB CLIN MED, V75, P1020

[10] RELATIONSHIP BETWEEN AGE AND HALOTHANE REQUIREMENT IN MAN [J].

GREGORY, GA ;

EGER, EI ;

MUNSON, ES .

ANESTHESIOLOGY, 1969, 30 (05) :488-&

← 1 2 3 4 →