SUCCESSFUL TREATMENT OF INVASIVE ASPERGILLOSIS COMPLICATING PROLONGED TREATMENT-RELATED NEUTROPENIA IN ACUTE MYELOGENOUS LEUKEMIA WITH AMPHOTERICIN-B LIPID COMPLEX

被引：22

作者：

HOSPENTHAL, DR ^{[1
]}

BYRD, JC ^{[1
]}

WEISS, RB ^{[1
]}

机构：

[1] WALTER REED ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,WASHINGTON,DC 20307

来源：

MEDICAL AND PEDIATRIC ONCOLOGY | 1995年 / 25卷 / 02期

关键词：

ASPERGILLOSIS; LIPOSOME; AMPHOTERICIN B; LEUKEMIA; NEUTROPENIA;

D O I：

10.1002/mpo.2950250214

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Herein we report the successful treatment of invasive aspergillosis with the liposomal amphotericin B (AMB) formulation, Amphotericin and Lipid Complex (ABLC(TM)). This investigational compound was employed in a 50-year-old patient with acute myelomonocytic leukemia complicated by prolonged, treatment-induced granulocytopenia and documented Aspergillus flavus sinusitis with signs of disseminated aspergillosis. The patient demonstrated radiographic signs of pulmonary aspergillosis and biochemical signs of hepatic involvement that were resistant to a 23 day course of conventional AMB (Fungizone(R)) therapy. Following therapy with ABLC(TM) her fever abated, her chest X-ray findings improved, and her hepatic function tests improved with eventual resolution. (C) 1995 Wiley-Liss, Inc.

引用

页码：119 / 122

页数：4

共 18 条

[1]

ALLENDOERFER R, 1992, J MED VET MYCOL, V30, P377

[2] FAVORABLE OUTCOME OF INVASIVE ASPERGILLOSIS IN PATIENTS WITH ACUTE-LEUKEMIA [J].

BURCH, PA ;

KARP, JE ;

MERZ, WG ;

KUHLMAN, JE ;

FISHMAN, EK .

JOURNAL OF CLINICAL ONCOLOGY, 1987, 5 (12) :1985-1993

[3]

BYRD JC, 1993, BLOOD S1, V82, P138

[4] AMPHOTERICIN-B LIPID COMPLEX THERAPY OF EXPERIMENTAL FUNGAL-INFECTIONS IN MICE [J].

CLARK, JM ;

WHITNEY, RR ;

OLSEN, SJ ;

GEORGE, RJ ;

SWERDEL, MR ;

KUNSELMAN, L ;

BONNER, DP .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (04) :615-621

[5] COMPARATIVE EFFICACIES OF AMPHOTERICIN-B LIPID COMPLEX AND AMPHOTERICIN-B DEOXYCHOLATE SUSPENSION AGAINST MURINE BLASTOMYCOSIS [J].

CLEMONS, KV ;

STEVENS, DA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (10) :2144-2146

[6]

DENNING DW, 1990, REV INFECT DIS, V12, P1147

[7] ITRACONAZOLE THERAPY IN ASPERGILLOSIS - STUDY IN 49 PATIENTS [J].

DUPONT, B .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1990, 23 (03) :607-614

[8] USE OF GRANULOCYTE-COLONY-STIMULATING FACTOR BEFORE, DURING, AND AFTER FLUDARABINE PLUS CYTARABINE INDUCTION THERAPY OF NEWLY-DIAGNOSED ACUTE MYELOGENOUS LEUKEMIA OR MYELODYSPLASTIC SYNDROMES - COMPARISON WITH FLUDARABINE PLUS CYTARABINE WITHOUT GRANULOCYTE-COLONY-STIMULATING FACTOR [J].

ESTEY, E ;

THALL, P ;

ANDREEFF, M ;

BERAN, M ;

KANTARJIAN, H ;

OBRIEN, S ;

ESCUDIER, S ;

ROBERTSON, LE ;

KOLLER, C ;

KORNBLAU, S ;

PIERCE, S ;

FREIREICH, E ;

DEISSEROTH, A ;

KEATING, M .

JOURNAL OF CLINICAL ONCOLOGY, 1994, 12 (04) :671-678

[9]

HIDDEMANN W, 1993, BLOOD S1, V82, P199

[10] COMPARATIVE SAFETY, TOLERANCE, AND PHARMACOKINETICS OF AMPHOTERICIN-B LIPID COMPLEX AND AMPHOTERICIN-B DEOXYCHOLATE IN HEALTHY MALE-VOLUNTEERS [J].

KAN, VL ;

BENNETT, JE ;

AMANTEA, MA ;

SMOLSKIS, MC ;

MCMANUS, E ;

GRASELA, DM ;

SHERMAN, JW .

JOURNAL OF INFECTIOUS DISEASES, 1991, 164 (02) :418-421

← 1 2 →