CYCLIN-E IS EXPRESSED IN NEURONS AND FORMS COMPLEXES WITH CDK5

被引：62

作者：

MIYAJIMA, M ^{[1
]}

NORNES, HO ^{[1
]}

NEUMAN, T ^{[1
]}

机构：

[1] COLORADO STATE UNIV, DEPT ANAT & NEUROBIOL, FT COLLINS, CO 80523 USA

来源：

NEUROREPORT | 1995年 / 6卷 / 08期

关键词：

CYCLIN E; CDK2; CDK5; CEREBRAL CORTEX; SPINAL CORD; DEVELOPMENT;

D O I：

10.1097/00001756-199505300-00014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

EXPRESSION Of cyclin dependent kinase cdk5 and its regulator p35 has been shown in the cytoplasm of adult neurons. Here we demonstrate that another potential regulator of cdk5, cyclin E, is expressed in the nervous system and forms complexes with cdk5. Western blot analyses identifies expression of two forms of cyclin E in the mouse nervous system with the 56 kDa form mainly expressed in neurons and 51 kDa form expressed in astrocytes and oligodendrocytes.

引用

页码：1130 / 1132

页数：3

共 27 条

[1] STRUCTURE AND EXPRESSION OF THE MURINE RETINOBLASTOMA GENE AND CHARACTERIZATION OF ITS ENCODED PROTEIN [J].

BERNARDS, R ;

SCHACKLEFORD, GM ;

GERBER, MR ;

HOROWITZ, JM ;

FRIEND, SH ;

SCHARTL, M ;

BOGENMANN, E ;

RAPAPORT, JM ;

MCGEE, T ;

DRYJA, TP ;

WEINBERG, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (17) :6474-6478

[2] OPTIMIZED SURVIVAL OF HIPPOCAMPAL-NEURONS IN B27-SUPPLEMENTED NEUROBASAL(TM), A NEW SERUM-FREE MEDIUM COMBINATION [J].

BREWER, GJ ;

TORRICELLI, JR ;

EVEGE, EK ;

PRICE, PJ .

JOURNAL OF NEUROSCIENCE RESEARCH, 1993, 35 (05) :567-576

[3]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[4] MOLECULAR-CLONING AND CHARACTERIZATION OF MURINE CYCLIN-E [J].

DAMJANOV, I ;

SHAN, J ;

WANG, RF ;

DAMJANOV, A ;

DELOIA, JA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 201 (02) :994-1000

[5]

FURUKAWA Y, 1994, J BIOL CHEM, V269, P26249

[6] A CDNA-ENCODING A PRB-BINDING PROTEIN WITH PROPERTIES OF THE TRANSCRIPTION FACTOR E2F [J].

HELIN, K ;

LEES, JA ;

VIDAL, M ;

DYSON, N ;

HARLOW, E ;

FATTAEY, A .

CELL, 1992, 70 (02) :337-350

[7] E1A-DEPENDENT TRANS-ACTIVATION OF THE HUMAN MYC PROMOTER IS MEDIATED BY THE E2F FACTOR [J].

HIEBERT, SW ;

LIPP, M ;

NEVINS, JR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (10) :3594-3598

[8] EXPRESSION OF CDK5 (PSSALRE KINASE), A NEURAL CDC2-RELATED PROTEIN-KINASE, IN THE MATURE AND DEVELOPING MOUSE CENTRAL AND PERIPHERAL NERVOUS SYSTEMS [J].

INO, H ;

ISHIZUKA, T ;

CHIBA, T ;

TATIBANA, M .

BRAIN RESEARCH, 1994, 661 (1-2) :196-206

[9] IDENTIFICATION OF THE 23 KDA SUBUNIT OF TAU-PROTEIN KINASE-II AS A PUTATIVE ACTIVATOR OF CDK5 IN BOVINE BRAIN [J].

ISHIGURO, K ;

KOBAYASHI, S ;

OMORI, A ;

TAKAMATSU, M ;

YONEKURA, S ;

ANZAI, K ;

IMAHORI, K ;

UCHIDA, T .

FEBS LETTERS, 1994, 342 (02) :203-208

[10]

Juurlink BHJ, 1992, NEUROMETHODS, P269

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